Altered spontaneous brain activity in obsessive-compulsive personality disorder

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成果类型：

期刊论文

作者：

Lei, Hui*;Huang, Li;Li, Jingxuan;Liu, Wanting;Fan, Jie;...

通讯作者：

Lei, Hui;Rao, Hengyi

作者机构：

[Huang, Li; Li, Jingxuan; Lei, Hui] Hunan Agr Univ, Coll Educ, Changsha, Hunan, Peoples R China.

[Fan, Jie; Zhang, Xiaocui; Xia, Jie; Zhu, Xiongzhao; Liu, Wanting] Cent South Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha, Hunan, Peoples R China.

[Fan, Jie; Xia, Jie; Zhu, Xiongzhao] Ctr South Univ, Med Psychol Inst, Changsha, Hunan, Peoples R China.

[Rao, Hengyi] Shanghai Int Studies Univ, Lab Appl Brain & Cognit Sci, Shanghai, Peoples R China.

[Zhang, Xiaocui; Zhao, Ke; Rao, Hengyi; Liu, Wanting; Lei, Hui] Univ Penn, Perelman Sch Med, Dept Neurol, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA.

通讯机构：

[Lei, Hui] H

[Rao, Hengyi] U

Hunan Agr Univ, Coll Educ, Changsha, Hunan, Peoples R China.

Univ Penn, Dept Neurol, Perelman Sch Med, Philadelphia, PA 19104 USA.

语种：

英文

关键词：

Obsessive-compulsive personality disorder;Resting-state functional MRI;Amplitude of low-frequency fluctuation;Spontaneous neuronal activity

期刊：

Comprehensive Psychiatry

ISSN：

0010-440X

年：

2020

卷：

页码：

152144

DOI：

10.1016/j.comppsych.2019.152144

基金类别：

This work was supported by grants from the National Natural Science Foundation of China , China (grant number 31600893 to Hui Lei).

机构署名：

本校为第一且通讯机构

院系归属：

教育学院

摘要：

Background: Obsessive-compulsive personality disorder (OCPD) is one of the most prevalent personality disorders in general population. However, neural mechanisms underlying OCPD remain elusive. The aim of this study is to use functional magnetic resonance imaging (fMRI) to examine whether OCPD patients will exhibit altered spontaneous brain activity as compared to healthy controls (HC). Methods: Resting-state fMRI data were acquired in 37 OCPD patients and 37 matched HC. Amplitudes of low-frequency fluctuation (ALIT) were calculated and compared between the two groups. Correlation analysis was...

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Altered spontaneous brain activity in obsessive-compulsive personality disorder

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