Nickel-Catalyzed Chemoselective Asymmetric Hydrogenation of α,β-Unsaturated Ketoimines: An Efficient Approach to Chiral Allylic Amines

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成果类型：

期刊论文

作者：

Zhao, Xiang;Zhang, Feng;Liu, Kai;Zhang, Xumu;Lv, Hui*

通讯作者：

Lv, Hui

作者机构：

[Zhao, Xiang; Liu, Kai; Lv, Hui] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China.

[Zhao, Xiang; Liu, Kai; Lv, Hui] Wuhan Univ, Coll Chem & Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat, Minist Educ,Sauvage Ctr Mol Sci, Wuhan 430072, Hubei, Peoples R China.

[Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.

[Lv, Hui] Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China.

[Zhang, Xumu] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Guangdong, Peoples R China.

通讯机构：

[Lv, Hui] W

[Lv, Hui] C

Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Hubei, Peoples R China.

Wuhan Univ, Coll Chem & Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat, Minist Educ,Sauvage Ctr Mol Sci, Wuhan 430072, Hubei, Peoples R China.

Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China.

语种：

英文

期刊：

Organic Letters

ISSN：

1523-7060

年：

2019

卷：

期：

页码：

8966-8969

DOI：

10.1021/acs.orglett.9b03365

基金类别：

We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21871212, 21402145), the Natural Science Foundation of Hubei Province (2018CFB430), and the open foundation of CAS Key Laboratory of Molecular Recognition and Function. We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21871212, 21402145) the Natural Science Foundation of Hubei Province (2018CFB430), and the open foundation of CAS Key Laboratory of Molecular Recognition and Function.

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本校为其他机构

院系归属：

理学院

摘要：

An efficient synthetic route to chiral allylic amines has been developed by nickel/(S,S)-Ph-BPE complex catalyzed chemoselective asymmetric hydrogenation of α,β-unsaturated ketoimines. Varieties of α,β-unsaturated ketoimines have been well tolerated in this transformation to give chiral allylic amines with high yields and excellent ee values (up to 99% yield, up to 99% ee). A gram-scale reaction with 0.2 mol % catalyst loading has also...

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Nickel-Catalyzed Chemoselective Asymmetric Hydrogenation of α,β-Unsaturated Ketoimines: An Efficient Approach to Chiral Allylic Amines

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