Epigallocatechin gallate alleviates osteoporosis by regulating the gut microbiota and serum metabolites in rats

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成果类型：

期刊论文

作者：

Han, Xuebing;Fu, Yifeng;Wang, Keyu;Li, Siying;Jiang, Chang;...

通讯作者：

Liu, Gang;Hu, SW

作者机构：

[Liu, Gang; Han, Xuebing; Hu, Siwang; Fu, Yifeng; Liu, G; Hu, SW; Li, Siying; Wang, Keyu; Jiang, Chang] Wenzhou Med Univ, Affiliated Wenling Hosp, Peoples Hosp Wenling 1, Orthopaed Ctr, Wenling 317500, Zhejiang, Peoples R China.

[Han, Xuebing; Wang, Zheng] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Han, Xuebing; Wang, Zheng] Hunan Engn Lab Pollut Control & Waste Utilizat Swi, Changsha 410128, Peoples R China.

[Wang, Shuangshuang] Wenzhou Med Univ, Affiliated Wenling Hosp, Peoples Hosp Wenling 1, Dept Cardiol, Wenling 317500, Zhejiang, Peoples R China.

[Wang, Shuangshuang] Ningbo Univ, Affiliated Hosp 1, Key Lab Precis Med Atherosclerot Dis Zhejiang Prov, Ningbo 315010, Peoples R China.

通讯机构：

[Liu, G; Hu, SW ] W

Wenzhou Med Univ, Affiliated Wenling Hosp, Peoples Hosp Wenling 1, Orthopaed Ctr, Wenling 317500, Zhejiang, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2023

卷：

期：

页码：

10564-10580

DOI：

10.1039/d3fo03233g

基金类别：

This research was supported by the grants from the Zhejiang Provincial Program for Medicine and Health (2022KY446, 2022KY447, 2023KY411, 2023KY1345 and 2023KY1347), the Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, [2022KY446, 2022KY447, 2023KY411, 2023KY1345, 2023KY1347]; Zhejiang Provincial Program for Medicine and Health [2022E10026]; Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province, China [21ywb115, 21ywb118, 20ywb143]; Social Development Science and Technology Foundation of Taizhou [2020S0180083, 2021S00156, 2021S00197, 2020S0180127]; Social Development Science and Technology Foundation of Wenling

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本校为其他机构

院系归属：

生物科学技术学院

摘要：

Osteoporosis, one of the serious public health problems worldwide, can lead to degeneration of the bone structure and increased risk of fractures. Epigallocatechin gallate (EGCG) is a natural product with potential efficacy in inhibiting bone loss. However, the specific mechanism remains unclear. This study first investigated the role of EGCG in preventing dexamethasone (DEX)-induced osteoporosis by regulating intestinal microbiota and serum metabolites. We detected the bone density, bone microstructure, and changes in intestinal microorganisms and serum metabolites. According to our results, ...

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Epigallocatechin gallate alleviates osteoporosis by regulating the gut microbiota and serum metabolites in rats

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