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Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon

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成果类型:
期刊论文
作者:
Zhang, Li;Wang, Hao-li;Zhang, Ya-fang;Mao, Xin-tao;Wu, Ting-ting;...
通讯作者:
Jin, J;Li, YY
作者机构:
[Jiang, Wan-jun; Zhang, Li; Mao, Xin-tao; Jin, Jin] Sun Yat Sen Univ, Affiliated Hosp 3, Ctr Neuroimmunol & Hlth Longev, Guangzhou 510630, Peoples R China.
[Jiang, Wan-jun; Zhang, Li; Cao, Qian; Jin, Jin; Huang, Zhi-hui; Wu, Ting-ting] Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Gastroenterol, Hangzhou 310016, Peoples R China.
[Yang, Bing; Fan, Ke-qi; Jiang, Wan-jun; Zhong, Jiang-yan; Wang, Hao-li; Zhang, Ya-fang; Jin, Jin; Liu, Dan-dan] Zhejiang Univ, Life Sci Inst, MOE Key Lab Biosyst Homeostasis & Protect, Zhejiang Prov Key Lab Canc Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China.
[Jiang, Wan-jun] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
[Zhuang, Mei-hui; Huang, Guang-ming] Univ Sci & Technol China, Sch Chem & Mat Sci, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China.
通讯机构:
[Jin, J ; Li, YY ] S
Sun Yat Sen Univ, Affiliated Hosp 3, Ctr Neuroimmunol & Hlth Longev, Guangzhou 510630, Peoples R China.
Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Gastroenterol, Hangzhou 310016, Peoples R China.
Zhejiang Univ, Life Sci Inst, MOE Key Lab Biosyst Homeostasis & Protect, Zhejiang Prov Key Lab Canc Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China.
Southeast Univ, Jiangsu Prov High Tech Key Lab Biomed Res, Key Lab Dev Genes & Human Dis, Minist Educ,Inst Life Sci, Nanjing 210096, Peoples R China.
语种:
英文
关键词:
Animals;Dendritic Cells;Diarrhea;Humans;Interferon Type I;Irritable Bowel Syndrome;Male;Mice;Mice, Inbred C57BL;Spermidine;Stress, Psychological;adeno associated virus vector;adenosine A1 receptor;adenosine A2a receptor;adenosine A2b receptor;adenosine A3 receptor;alpha interferon;calcium channel;cefoxitin;collagen gel;fludarabine;gentamicin;guanine;guanosine;hemoglobin beta chain;heterodimer;homodimer;hydrocortisone;inosine;metronidazole;molecular motor;mucin 2;ornithine decarboxylase;serotonin;spermidine;STAT1 protein;STAT2 protein;tumor necrosis factor receptor associated factor 3;vancomycin;xanthine;interferon;spermidine;abdominal discomfort;animal cell;animal experiment;animal model;animal tissue;Article;blood level;calcium transport;CD4+ T lymphocyte;colonic muscle;controlled study;decarboxylation;defecation;diarrhea;differential gene expression;down regulation;electric shock;electromyogram;emotional disorder;enterochromaffin cell;gene ontology;HEK293T cell line;homologous recombination;human;human cell;immobilization stress;inflammation;interferon signaling;intestine cell;intestine flora;irritable colon;KEGG;Lactobacillus;Lactobacillus murinus;liquid chromatography-mass spectrometry;mental stress;metabolomics;mouse;mucus;multiomics;muscle contraction;myeloid dendritic cell;myofibroblast;nonhuman;pathogenesis;pathway enrichment analysis;plasmacytoid dendritic cell;polyubiquitination;promoter region;protein expression;protein phosphorylation;purine synthesis;single cell RNA seq;smooth muscle cell;supplementation;ubiquitination;visceral hyperalgesia;water content;withdrawal reflex;Zung Self Rating Anxiety Scale;animal;C57BL mouse;complication;dendritic cell;diarrhea;irritable colon;male;mental stress;metabolism
期刊:
Cell Metabolism
ISSN:
1550-4131
年:
2025
卷:
37
期:
1
页码:
87-103.e10
基金类别:
Zhejiang University, ZJU Changsha Science and Technology Project, (BK20211168, 82202019/82301968) Changsha Science and Technology Project Higher Education Discipline Innovation Project, (D20036) Higher Education Discipline Innovation Project Natural Science Foundation of Zhejiang Province, ZJNSF, (LHDMD22H100002, LQ21H030013) Natural Science Foundation of Zhejiang Province, ZJNSF China Postdoctoral Science Foundation, (2022M723664/2023M734007) China Postdoctoral Science Foundation National Natural Science Foundation of China, NSFC, (82230061, 82125016) National Natural Science Foundation of China, NSFC National Key Research and Development Program of China, NKRDPC, (2018YFD0500100, 82071046, 82100540) National Key Research and Development Program of China, NKRDPC
机构署名:
本校为其他机构
院系归属:
生物科学技术学院
摘要:
Irritable bowel syndrome with diarrhea (IBS-D) is a common and chronic gastrointestinal disorder that is characterized by abdominal discomfort and occasional diarrhea. The pathogenesis of IBS-D is thought to be related to a combination of factors, including psychological stress, abnormal muscle contractions, and inflammation and disorder of the gut microbiome. However, there is still a lack of comprehensive analysis of the logical regulatory correlation among these factors. In this study, we found that stress induced hyperproduction of xanthine...

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