Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon

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成果类型：

期刊论文

作者：

Zhang, Li;Wang, Hao-li;Zhang, Ya-fang;Mao, Xin-tao;Wu, Ting-ting;...

通讯作者：

Jin, J;Li, YY

作者机构：

[Jiang, Wan-jun; Zhang, Li; Mao, Xin-tao; Jin, Jin] Sun Yat Sen Univ, Affiliated Hosp 3, Ctr Neuroimmunol & Hlth Longev, Guangzhou 510630, Peoples R China.

[Jiang, Wan-jun; Zhang, Li; Cao, Qian; Jin, Jin; Huang, Zhi-hui; Wu, Ting-ting] Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Gastroenterol, Hangzhou 310016, Peoples R China.

[Yang, Bing; Fan, Ke-qi; Jiang, Wan-jun; Zhong, Jiang-yan; Wang, Hao-li; Zhang, Ya-fang; Jin, Jin; Liu, Dan-dan] Zhejiang Univ, Life Sci Inst, MOE Key Lab Biosyst Homeostasis & Protect, Zhejiang Prov Key Lab Canc Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China.

[Jiang, Wan-jun] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

[Zhuang, Mei-hui; Huang, Guang-ming] Univ Sci & Technol China, Sch Chem & Mat Sci, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China.

通讯机构：

[Jin, J ; Li, YY ] S

Sun Yat Sen Univ, Affiliated Hosp 3, Ctr Neuroimmunol & Hlth Longev, Guangzhou 510630, Peoples R China.

Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Gastroenterol, Hangzhou 310016, Peoples R China.

Zhejiang Univ, Life Sci Inst, MOE Key Lab Biosyst Homeostasis & Protect, Zhejiang Prov Key Lab Canc Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China.

Southeast Univ, Jiangsu Prov High Tech Key Lab Biomed Res, Key Lab Dev Genes & Human Dis, Minist Educ,Inst Life Sci, Nanjing 210096, Peoples R China.

语种：

英文

关键词：

AdorA2B;Lactobacillus murinus;irritable bowel syndrome with diarrhea;spermidine;stress;type I interferon;xanthine

期刊：

Cell Metabolism

ISSN：

1550-4131

年：

2025

卷：

期：

页码：

87-103.e10

DOI：

10.1016/j.cmet.2024.09.002

基金类别：

Distinguished Young Scientist fund of NSFC [82125016]; National Natural Science Foundation of China [82071046, 82100540]; Zhejiang Provincial Natural Science Foundation of China [LHDMD22H100002, LQ21H030013]; National Key Research and Development Program of China [2018YFD0500100]; Jiangsu Science and Technology Project (Social Development) [BK20211168]; Young Scientists fund of the National Natural Science Foundation of China [82202019/82301968]; China Postdoctoral Science Foundation [2022M723664/2023M734007]; The 111 Program [D20036]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

Irritable bowel syndrome with diarrhea (IBS-D) is a common and chronic gastrointestinal disorder that is characterized by abdominal discomfort and occasional diarrhea. The pathogenesis of IBS-D is thought to be related to a combination of factors, including psychological stress, abnormal muscle contractions, and inflammation and disorder of the gut microbiome. However, there is still a lack of comprehensive analysis of the logical regulatory correlation among these factors. In this study, we found that stress induced hyperproduction of xanthine...

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Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon

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