Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chang, Renxu;Jia, Hongdou;Dong, Zhihao;Xu, Qiushi;Liu, Lei;...

通讯作者：

Yang, Q;Sun, XD

作者机构：

[Chang, Renxu; Liu, Lei; Yang, Qing] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Sun, Xudong; Chang, Renxu; Jia, Hongdou; Dong, Zhihao; Xu, Qiushi; Sun, XD] Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Heilongjiang Prov Key Lab Prevent & Control Bovine, Daqing 163319, Peoples R China.

[Chang, Renxu; Xu, Chuang] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China.

[Majigsuren, Zolzaya] Mongolian Univ Life Sci, Inst Vet Med, Ulaanbaatar 17024, Mongolia.

[Batbaatar, Tugsjargal] State Cent Vet Lab, Ulaanbaatar 210153, Mongolia.

通讯机构：

[Yang, Q ; Sun, XD ] H

Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Heilongjiang Prov Key Lab Prevent & Control Bovine, Daqing 163319, Peoples R China.

语种：

英文

关键词：

bovine mammary epithelial cells;NLRP3;Mito-ROS;apoptosis

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2023

卷：

期：

页码：

12645–12656

DOI：

10.1021/acs.jafc.3c02090

基金类别：

National Natural Science Foundation of China (Beijing, China) [32072931, 32211530481]; Postdoctoral Scientific Research Development Fund of Heilongjiang (Heilongjiang, China) [LBH-Q21038]; Earmarked Fund for CARS36; Postgraduate Scientific Research Innovation Project of Hunan Province (Hunan, China) [QL20220164]; Natural Science Foundation of Heilongjiang Province [LH2021C073]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Early lactation increases metabolic stress in ketotic dairy cows, leading to mitochondrial damage, apoptosis, and inflammatory response in mammary epithelial cells. The pyrin domain 3 (NLRP3) pathway involving the mitochondrial reactive oxygen species (Mito-ROS)-induced nucleotide-binding oligomerization domain-like receptor has been recognized as a key mechanism in this inflammatory response and cell apoptosis. This study aimed to elucidate the underlying regulatory mechanism of Mito-ROS-NLRP3 pathway-mediated mammary epithelial cell apoptosis in dairy cows with ketosis. Mitochondrial damage ...

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Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway

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