The Carboxyl Terminus of the Porcine Circovirus Type 2 Capsid Protein Is Critical to Virus-Like Particle Assembly, Cell Entry, and Propagation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhan, Yang;Yu, Wanting;Cai, Xiong;Lei, Xinnuo;Lei, Hongyu;...

通讯作者：

Yang, Yi

作者机构：

[Zhan, Yang; Wang, Naidong; Wang, Aibing; Yu, Wanting; Lei, Hongyu; Deng, Zhibang; Lei, Xinnuo; Yang, Yi] Hunan Agr Univ, Prov Key Lab Prot Engn Anim Vaccines, RCRV, Coll Vet Med, Changsha, Hunan, Peoples R China.

[Zhan, Yang; Wang, Naidong; Wang, Aibing; Yu, Wanting; Lei, Hongyu; Deng, Zhibang; Lei, Xinnuo; Yang, Yi] Hunan Agr Univ, LFP, Coll Vet Med, Changsha, Hunan, Peoples R China.

[Cai, Xiong] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha, Hunan, Peoples R China.

[Sun, Yujie] Peking Univ, Biodynam Opt Imaging Ctr BIOPIC, Sch Life Sci, State Key Lab Membrane Biol, Beijing, Peoples R China.

通讯机构：

[Yang, Yi] H

Hunan Agr Univ, Prov Key Lab Prot Engn Anim Vaccines, RCRV, Coll Vet Med, Changsha, Hunan, Peoples R China.

Hunan Agr Univ, LFP, Coll Vet Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Cap;PCV2;intrinsically disordered regions;loop

期刊：

Journal of Virology

ISSN：

0022-538X

年：

2020

卷：

期：

DOI：

10.1128/JVI.00042-20

基金类别：

National Key R&D Program of China [2017YFA0505300]; Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines [2017TP1014]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ2177, 2018JJ2293]; Hunan Education Department's Science & Research Project [17K069, 18B092]; Postgraduate Research and Innovation Project of Hunan Province [CX2018B394]; double first-class construction project of Hunan Agricultural University [SYL2019048]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

The capsid protein (Cap) is the sole structural protein and the main antigen of porcine circovirus type 2 (PCV2). Structural loops of the Cap play crucial roles in viral genome packaging, capsid assembly, and virus-host interactions. Although the molecular mechanisms are yet unknown, the carboxyl terminus (CT) of the PCV2 Cap is known to play critical roles in the evolution, pathogenesis, and proliferation of this virus. In this study, we investigated functions of CT. Removal of this loop leads to abrogation of the in vitro Cap self-assembly in...

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The Carboxyl Terminus of the Porcine Circovirus Type 2 Capsid Protein Is Critical to Virus-Like Particle Assembly, Cell Entry, and Propagation

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