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Evidence of natural co-infection with PCV2b subtypes in vivo

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成果类型:
期刊论文
作者:
Hu, Yi;Zhan, Yang;Wang, Dongliang;Xie, Xiaohong;Liu, Tanbin;...
通讯作者:
Wang, Aibing
作者机构:
[Hu, Yi; Liu, Tanbin; Liu, Wei; Wang, Aibing; Lei, Hongyu] Hunan Agr Univ, Coll Vet Med, Res Ctr Reverse Vaccinol RCRV, Lab Anim Models & Funct Genom LAMFG, Changsha 410128, Hunan, Peoples R China.
[Zhan, Yang; Xie, Xiaohong; Wang, Naidong; Wang, Dongliang; Deng, Zhibang; Yang, Yi] Hunan Agr Univ, Coll Vet Med, Res Ctr Reverse Vaccinol RCRV, Lab Funct Prote LFP, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Wang, Aibing] H
Hunan Agr Univ, Coll Vet Med, Res Ctr Reverse Vaccinol RCRV, Lab Anim Models & Funct Genom LAMFG, Changsha 410128, Hunan, Peoples R China.
语种:
英文
关键词:
PCV2 Strain;Major Open Reading Frame;PCV2 Genome;PCV2 Genotype;Porcine Circoviruses
期刊:
Archives of Virology
ISSN:
0304-8608
年:
2017
卷:
162
期:
7
页码:
2015-2020
基金类别:
General Program of National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31270819, 31571432]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [13JJ1022/S2013J5050/2015JC3097]; Research Foundation of Hunan Provincial Education Department, China [15A086]; Planning Programs of Hunan Provincial Science and Technology, China [2015JC3097]; Post-graduate Research and Innovation Project of Hunan Province [CX2016B285, CX2016B314]
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
Porcine circovirus type 2 (PCV2) is the causative pathogen of porcine circovirus-associated diseases (PCVAD). This virus evolves mostly through point mutations and genome recombination between different PCV2 genotypes (e.g. PCV2a and PCV2b), as has been confirmed in swine herds. In the current work, the complete PCV2 genome sequences of 69 clones derived from various tissues (lymph node, spleen and lung,) of an infected individual, were subjected to phylogenetic and alignment analyses. The results not only demonstrate co-infection with distinct PCV2b subtypes (e.g. 1B and 1C) in the same anima...

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