期刊论文

Yi, Jine(yijine@hunau.edu.cn);Zhu, Lijuan(zhulijuan@stu.hunau.edu.cn)

英文

FOOD & FUNCTION

2042-6496

2022

13

22

11489-11502

10.1039/d2fo01042a

This paper was supported by the Natural Science Foundation of Hunan Province, China (Grant No. 2020JJ4368 and 2021JJ30343), the Special Funds for Construction of Innovative Provinces in Hunan Province, China (Grant No. 2020NK2032), and the Innovation Research and Development Project of Hunan Development and Reform Commission (Grant No. 202114).

本校为第一机构

Endoplasmic reticulum stress (ERS) plays a vital role in the pathogenesis of the alcoholic liver disease (ALD). Betulinic acid (BA) has been reported to be effective in the attenuation of ALD; however, its role in ERS and associated stress-signaling pathways remains elusive. Here, we found that the BA pretreatment significantly reduced the alcohol-induced liver injury by decreasing the activities of serum alanine aminotransferase and aspartate aminotransferase, alleviating fat deposition and rupturing the ER in hepatocytes. Moreover, the protec...