Comparative proteomic analysis using 2DE-LC-MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease

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成果类型：

期刊论文

作者：

Liu, Zhonghua;Lin, Yong;Zhang, Sheng;Wang, Die;Liang, Qionglin;...

通讯作者：

Luo, Guoan

作者机构：

[Liu, Zhonghua; Luo, Guoan; Liang, Qionglin] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China.

[Liu, Zhonghua; Luo, Guoan; Liang, Qionglin] Minist Educ, Key Lab Biol Organ Phosphorus & Chem Biol, Beijing, Peoples R China.

[Liu, Zhonghua; Lin, Yong; Zhang, Sheng] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct In, Changsha, Hunan, Peoples R China.

[Liu, Zhonghua; Wang, Die] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Coll Hort & Landscape, Changsha, Hunan, Peoples R China.

通讯机构：

[Luo, Guoan] T

Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China.

语种：

英文

关键词：

Ameliorative mechanism;Comparative proteomics;Fat accumulation;Fuzhuan brick tea extract (FTE);Nonalcoholic fatty liver disease

期刊：

ELECTROPHORESIS

ISSN：

0173-0835

年：

2015

卷：

期：

页码：

2002-2016

DOI：

10.1002/elps.201500076

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31100502]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [12B064]; Specialized Research Foundation for the doctorial Program of Higher Education of China [20114320120004]; Key Project of National Technology Innovation System for Tea Industry in the People's Republic of China [CARS-23]; Foundation for Innovation Research Team of Ministry of Education [IRT0963]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [13JJ4067]; 1515 Talents Project of Hunan Agricultural University

机构署名：

本校为其他机构

院系归属：

园艺园林学院

摘要：

Fuzhuan brick tea has received increasing attention in recent years owing to its benefits for non-alcoholic fatty liver disease (NAFLD) and associated metabolic syndrome. For exploring the ameliorative mechanism, the liver proteomes from three groups of rats fed either a normal control diet (NCD), a high fat diet (HFD), or a HFD supplemented with high-dose FTE (HFD+HFTE) were comprehensively compared by quantitative proteomics using 2DE-LC-MS/MS. This is the first study of the effects of tea aqueous extract on the liver proteome of rats sufferi...

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Comparative proteomic analysis using 2DE-LC-MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease

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