The invention discloses a new application of a kadsura coccinea fruit extract, and particularly discloses application of a kadsura coccinea fruit alcohol extract in preparation of an anti-diarrhea drug. The method comprises the following steps: carrying out ultrasonic extraction on the kadsura coccinea fruits by using ethanol or methanol, and establishing a mouse diarrhea model by using Escherichia coli and folium sennae to stimulate to study the anti-diarrhea effect of the kadsura coccinea fruit extract. Detection on the diarrhea latent time, mouse diarrhea rate and diarrhea index shows thatt...