In this fig, natural capsinoids was synthesised from capsaicinoids by lipase-catalysis in acetone. The optimal reaction conditions as follows :50retool vanillyl alcohol and 75mmol methyl nonanoate in 1 mL of acetone containing 0. 1% - 0. 3% of water (V/V) in the presence of 20 mg lipase. Under the conditions, at 30℃ ,more than 60% of yield was achived after 9 h. The corresponding fatty acid methyl ester of capsaicinoids was obtained by menthanolysis of nature capsaicin in HC methanol and then the capsinoids was gained by the lipase-catalyze...