Grass carp IL-20 binds to IL-20R2 but induces STAT3 phosphorylation via IL-20R1

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成果类型：

期刊论文

作者：

Dang, Huifeng;Hassan, Zeinab;Jia, Zhao;Wu, Yaxin;Xiao, Hehe;...

通讯作者：

Wang, JY

作者机构：

[Hassan, Zeinab; Jia, Zhao; Guo, Xu; Wang, Junya; Zhao, Xin; Huang, Wenji; Wang, JY; Dang, Huifeng; Xiao, Hehe; Wu, Yaxin; Zou, Jun] Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China.

[Hassan, Zeinab; Jia, Zhao; Guo, Xu; Wang, Junya; Zhao, Xin; Huang, Wenji; Dang, Huifeng; Xiao, Hehe; Wu, Yaxin; Zou, Jun] Shanghai Ocean Univ, Int Res Ctr Marine Biosci, Minist Sci & Technol, Shanghai 201306, Peoples R China.

[Hassan, Zeinab; Jia, Zhao; Guo, Xu; Wang, Junya; Zhao, Xin; Huang, Wenji; Dang, Huifeng; Xiao, Hehe; Wu, Yaxin; Zou, Jun] Univ Shanghai, Natl Demonstrat Ctr Expt Fisheries Sci Educ, Shanghai 201306, Peoples R China.

[Hassan, Zeinab] Aswan Univ, Fac Vet Med, Dept Fish Dis, Airport Way, Sahari 81528, Egypt.

[Li, Yaoguo] Hunan Agr Univ, Hunan Engn Technol Res Ctr Featured Aquat Resource, Changsha 410128, Peoples R China.

通讯机构：

[Wang, JY ] S

Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai 201306, Peoples R China.

语种：

英文

关键词：

Evolution;Fish;IL-20 receptor;Interleukin 20;STAT3 phosphorylation

期刊：

Fish & Shellfish Immunology

ISSN：

1050-4648

年：

2023

卷：

132

页码：

108445

DOI：

10.1016/j.fsi.2022.11.033

基金类别：

This work is supported by the National Natural Science Foundation of China (Grant numbers: 32030112 and U21A20268 ) and Scientific Research Fund of Hunan Provincial Education Department (Grant number: 19B265 ).

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

IL-20 is a pleiotropic cytokine that belongs to the IL-10 family and has a variety of biological functions in tissue homeostasis and regulation of host immune defenses. It signals through a heterodimeric receptor composed of a subunit with a long intracellular domain (R1 type receptor) and a subunit with a short intracellular domain (R2 type receptor). In this study, the R1 type receptor (CiIL-20R1/CRFB8) and the R2 type receptor (CiIL-20R2/CRFB16) were identified in grass carp Ctenopharyngodon idella. Expression analysis revealed that IL-20R2 ...

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Grass carp IL-20 binds to IL-20R2 but induces STAT3 phosphorylation via IL-20R1

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