Genotoxicity of chlorpyrifos and cypermethrin to ICR mouse hepatocytes

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cui, Yong*;Guo, Jiangfeng;Xu, Bujin;Chen, Ziyuan

通讯作者：

Cui, Yong

作者机构：

[Cui, Yong] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Guo, Jiangfeng] Zhejiang Sci Tech Univ, Inst Bioengn, Hangzhou, Zhejiang, Peoples R China.

[Chen, Ziyuan; Xu, Bujin] Zhejiang Univ, Inst Nucl Agr Sci, Hangzhou 310003, Zhejiang, Peoples R China.

通讯机构：

[Cui, Yong] H

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Chlorpyrifos;Cypermethrin;DNA strand breakage;Excision-repairable DNA damage;Hypomethylation

期刊：

Toxicology Mechanisms and Methods

ISSN：

1537-6516

年：

2011

卷：

期：

页码：

70-74

DOI：

10.3109/15376516.2010.529192

基金类别：

Science and Technology Department of Zhejiang Province, China; Hunan Agricultural University, China

机构署名：

本校为第一且通讯机构

院系归属：

生物科学技术学院

摘要：

Massive application of pesticides had generated a considerable concern in the public. Potentials of chlorpyrifos [O,O-diethyl-O-(3,5,6-trichloro-2- pyridinyl) phosphorothionate] and cypermethrin [(RS)-α-cyano-3- phenoxybenzyl (1RS)-cis-trans-3-(2,2-dichlorovinyl)-2,2- dimethylcyclopropanecarboxylate] to induce the excision-repairable DNA damage, DNA strand breakage, and DNA hypomethylation in ICR mouse hepatocytes were investigated. It was showed that chlorpyrifos and cypermethrin didn't increase the incorporation of 3H-TdR into DNA of ICR mou...

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Genotoxicity of chlorpyrifos and cypermethrin to ICR mouse hepatocytes

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