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Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway

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成果类型:
期刊论文
作者:
Wen, Yi-Ling;He, Ziyu;Hou, De-Xing;Qin, Si
通讯作者:
Yi-Ling Wen<&wdkj&>De-Xing Hou<&wdkj&>Si Qin<&wdkj&>Ziyu He
作者机构:
[Qin, Si; Wen, Yi-Ling] Hunan Agr Univ, Coll Food Sci & Technol, Key Lab Food Sci & Biotechnol Hunan Prov, Changsha 410128, Peoples R China.
[He, Ziyu; Qin, Si; Hou, De-Xing] Kagoshima Univ, Fac Agr, United Grad Sch Agr Sci, Korimoto 1-21-24, Kagoshima 8900065, Japan.
通讯机构:
[Yi-Ling Wen; Si Qin] K
[De-Xing Hou; Ziyu He] T
Key Laboratory for Food Science and Biotechnology of Hunan Province,College of Food Science and Technology,Hunan Agricultural University,China<&wdkj&>The United Graduate School of Agricultural Sciences,Faculty of Agriculture,Kagoshima University,Japan<&wdkj&>The United Graduate School of Agricultural Sciences,Faculty of Agriculture,Kagoshima University,Japan<&wdkj&>Key Laboratory for Food Science and Biotechnology of Hunan Province,College of Food Science and Technology,Hunan Agricultural University,China
语种:
英文
关键词:
Introduction;Materials and Methods;Results;Discussion;Conclusion;Abstract;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interests;Authors’ Contributions;Funding Statement;Acknowledgements;Acknowledgments;Supplementary Materials;Reference;Dataset Description;Dataset Files;Abstract;Introduction;Introduction and Materials;Introduction and Methods;Materials;Materials and Methods;Methods;Results;Discussion;Results and Discussion;Discussion and Conclusion;Results and Conclusion;Conclusion;Conclusions;Data Availability;Additional Points;Ethical Approval;Consent;Disclosure;Conflicts of Interest;Authors’ Contributions;Funding Statement;Acknowledgements;Supplementary Materials;References;Appendix;Abbreviations;Preliminaries;Introduction and Preliminaries;Notation;Proof of Theorem;Proofs;Analysis of Results;Examples;Numerical Example;Applications;Numerical Simulation;Model;Model Formulation;Systematic Palaeontology;Nomenclatural Acts;Taxonomic Implications;Experimental;Synthesis;Overview;Characterization;Background;Experimental;Theories;Calculations;Model Verification;Model Implementation;Geographic location;Study Area;Geological setting;Data Collection;Field Testing;Data and Sampling;Dataset;Literature Review;Related Works;Related Work;System Model;Methods and Data;Experimental Results;Results and Analysis;Evaluation;Implementation;Case Presentation;Case Report;Search Terms;Case Description;Case Series;Background;Limitations;Additional Points;Case;Case 1;Case 2 etc.;Concern Details;Retraction Details;Copyright;Related Articles
期刊:
Oxidative Medicine and Cellular Longevity
ISSN:
1942-0900
年:
2021
卷:
2021
基金类别:
National Key Research and Development Program of China [2019YFC1604903]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31101268]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ40132]; Double First-Class Construction Project of Hunan Agricultural University [SYL201802025]
机构署名:
本校为第一机构
院系归属:
食品科学技术学院
摘要:
Crocetin is a main bioactive component with a carotenoid skeleton in Gardenia jasminoides, a typical traditional Chinese medicine with a long history in Southeast Asia. Crocetin is being commonly consumed as spices, dyes, and food colorants. Recent pharmacological studies had implied that crocetin may possess potent anti-inflammatory properties; however, the underlying molecular mechanism is not fully elucidated. In the present study, the regulatory effect of crocetin on redox balance was systematically investigated in lipopolysaccharide- (LPS-) stimulated RAW264.7 cells. The results showed th...

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