Inhibition of migration and induction of apoptosis in LoVo human colon cancer cells by polysaccharides from Ganoderma lucidum

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成果类型：

期刊论文

作者：

Liang, Zeng-Enni;Yi, You-Jin;Guo, Yu-Tong;Wang, Ren-Cai;Hu, Qiu-Long;...

通讯作者：

Xiong, Xing-Yao

作者机构：

[Liang, Zeng-Enni] Hunan Agr Prod Proc Inst, Changsha 410128, Hunan, Peoples R China.

[Hu, Qiu-Long; Liang, Zeng-Enni; Xiong, Xing-Yao; Wang, Ren-Cai] Hunan Agr Univ, Coll Hort & Landscape, Changsha 410128, Hunan, Peoples R China.

[Yi, You-Jin] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.

[Guo, Yu-Tong] State Adm Tradit Chinese Med, State Key Lab Subhlth Intervent Technol, Changsha 410128, Hunan, Peoples R China.

[Xiong, Xing-Yao] Hunan Agr Univ, Coll Hort & Landscape, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Xiong, Xing-Yao] H

Hunan Agr Univ, Coll Hort & Landscape, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Death receptor pathway;Ganoderma lucidum polysaccharides;Human colon cancer

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2015

卷：

期：

页码：

7629-7636

DOI：

10.3892/mmr.2015.4345

机构署名：

本校为通讯机构

院系归属：

园艺园林学院

食品科学技术学院

摘要：

Ganoderma lucidum polysaccharides (GLPs), which were purified from the medicinal herb G. lucidum followed by ethanol precipitation, protein depletion using the Sevage assay, purification using DEAE-cellulose (DE-52), dialysis and the use of ultrafiltration membranes, are used as an ingredient in traditional anticancer treatments in China. The aim of the current study was to evaluate the anticancer effects and investigate the underlying molecular mechanisms of GLPs on LoVo human colon cancer cells. The results demonstrated that the GLP-mediated anticancer effect in LoVo cells was characterized ...

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Inhibition of migration and induction of apoptosis in LoVo human colon cancer cells by polysaccharides from Ganoderma lucidum

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