A mitochondria-targeted colorimetric and ratiometric fluorescent probe for hydrogen peroxide with a large emission shift and bio-imaging in living cells

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成果类型：

期刊论文

作者：

Shen, Youming;Zhang, Xiangyang*;Zhang, Youyu*;Wu, Yanyang;Zhang, Chunxiang;...

通讯作者：

Zhang, Xiangyang;Zhang, Youyu

作者机构：

[Shen, Youming; Zhang, Xiangyang; Chen, Yuandao; Jin, Junling; Zhang, Chunxiang] Hunan Univ Arts & Sci, Coll Chem & Mat Engn, Hunan Prov Cooperat Innovat Ctr Construct & Dev D, Changde 415000, Peoples R China.

[Shen, Youming; Zhang, Youyu; Wu, Yanyang; Li, Haitao] Hunan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China.

[Wu, Yanyang] Hunan Agr Univ, Food Sci & Technol Coll, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Zhang, Xiangyang; Zhang, Youyu] H

Hunan Univ Arts & Sci, Coll Chem & Mat Engn, Hunan Prov Cooperat Innovat Ctr Construct & Dev D, Changde 415000, Peoples R China.

Hunan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China.

语种：

英文

关键词：

Colorimetric and ratiometric fluorescent;sensor;Mitochondria-targeted;Hydrogen peroxide;Living cell imaging

期刊：

Sensors and Actuators B-Chemical

ISSN：

0925-4005

年：

2018

卷：

255

期：

Pt.1

页码：

42-48

DOI：

10.1016/j.snb.2017.08.020

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21507028, 21675043]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [17B181, 15C0934]; Natural Science Foundation of Hunan Provincial [2017JJ2195]; Open Project Program of Key Laboratory of Preparation and Application of Environmentally Friendly Materials (Jilin Normal University), China [2017010]; Ministry of Education; Construct Program of the Key Discipline in Hunan Province (Applied Chemistry)

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本校为其他机构

院系归属：

食品科学技术学院

摘要：

A novel mitochondria-targeted fluorescent probe compound 1 for H2O2 has constructed based on a coumarin as the fluorophore and a boronate moiety as the reaction site, which showed colorimetric and ratiometric fluorescence dual response to H2O2. This probe displayed a large blue-shifted in emission wavelength (105 nm) with two well-resolved emission bands toward hydrogen peroxide. The compound 1 can be quantitative, good selective and sensitive recognition to H2O2 with low detection limit (10 nM). The sensing mechanism was confirmed by H NMR and HRMS spectroscopy. The mechanism regarding the op...

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A mitochondria-targeted colorimetric and ratiometric fluorescent probe for hydrogen peroxide with a large emission shift and bio-imaging in living cells

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