Ganoderma lucidum polysaccharides prevent palmitic acid-evoked apoptosis and autophagy in intestinal porcine epithelial cell line via restoration of mitochondrial function and regulation of MAPK and AMPK/Akt/mTOR signaling pathway

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成果类型：

期刊论文

作者：

Liang, Zengenni;Yuan, Zhihang;Guo, Jiajing;Wu, Jing;Yi, Jine;...

通讯作者：

Shan, Yang

作者机构：

[Guo, Jiajing; Liang, Zengenni] Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Hunan, Peoples R China.

[Wu, Jing; Yi, Jine; Yuan, Zhihang] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Deng, Jing; Shan, Yang] Hunan Acad Agr Sci, Changsha 410125, Hunan, Peoples R China.

通讯机构：

[Shan, Yang] H

Hunan Acad Agr Sci, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

beclin 1;caspase 3;mammalian target of rapamycin;mitogen activated protein kinase;palmitic acid;polysaccharide;protein Bax;protein bcl 2;sequestosome 1;biological marker;fungal polysaccharide;palmitic acid;protein kinase B;target of rapamycin kinase;Akt/mTOR signaling;AMPK signaling;animal cell;animal tissue;anion exchange chromatography;apoptosis;Article;autophagosome;autophagy;bioluminescence;cell death;cell proliferation;cell protection;cell survival;cell viability;cell viability assay;Chinese medicine;controlled study;cytotoxicity;enzyme linked immunosorbent assay;flow cytometry;Ganoderma lucidum;human;human cell;IC50;immunofluorescence test;immunoreactivity;lipid diet;lipid peroxidation;MAPK signaling;mitochondrial membrane potential;mitophagy;mouse;MTT assay;nonhuman;oxidative stress;pig;protein expression;protein phosphorylation;signal transduction;upregulation;Western blotting;animal;Basidiomycetes;cell line;chemistry;drug effect;epithelium cell;intestine mucosa;metabolism;mitochondrion;phosphorylation;Animals;Apoptosis;Autophagy;Basidiomycota;Biomarkers;Cell Line;Epithelial Cells;Fungal Polysaccharides;Intestinal Mucosa;Mitochondria;Mitogen-Activated Protein Kinases;Palmitic Acid;Phosphorylation;Proto-Oncogene Proteins c-akt;Signal Transduction;Swine;TOR Serine-Threonine Kinases

期刊：

International Journal of Molecular Sciences

ISSN：

1661-6596

年：

2019

卷：

期：

页码：

478

DOI：

10.3390/ijms20030478

基金类别：

This work was supported by the National Natural Science Foundation of China (grant number 31501484), Hunan Provincial Natural Science Foundation of China (grant number 2016JJ3081) and Hunan Agricultural Science and Technology Innovation Team Project (grant numbers 2017GC03, 2018QN27 and 2018ZD04).

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Ganoderma lucidum polysaccharide (GLP) extracted from Ganoderma lucidum (Leyss. ex Fr.) Karst, a traditional Chinese medicine, is a biologically active substance reported to possess anti-oxidative, anti-apoptotic, and neurological protection. However, it is unknown whether GLP have any protective effect against high-fat constituents-induced epithelial cell injury. The aim of this study was to investigate the protection and molecular mechanism of GLP on injury induced by palmitic acid (PA) in the intestinal porcine epithelial cell line (IPEC-J2)...

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Ganoderma lucidum polysaccharides prevent palmitic acid-evoked apoptosis and autophagy in intestinal porcine epithelial cell line via restoration of mitochondrial function and regulation of MAPK and AMPK/Akt/mTOR signaling pathway

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