Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse

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成果类型：

期刊论文

作者：

Chong-Yin Huang;Meng-Ting Zuo;Xue-Jia Qi;Meng-Die Gong;Wen-Bo Xu;...

通讯作者：

Xiao-Feng Zheng<&wdkj&>Zhao-Ying Liu

作者机构：

[Wen-Bo Xu; Chong-Yin Huang; Xue-Jia Qi; Zhi-Liang Sun; Meng-Die Gong; Jiang-Yu Long; Pi-Shun Li; Si-Yu Meng; Meng-Ting Zuo] College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China

[Wen-Bo Xu; Chong-Yin Huang; Xue-Jia Qi; Zhi-Liang Sun; Meng-Die Gong; Jiang-Yu Long; Pi-Shun Li; Si-Yu Meng; Meng-Ting Zuo] Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, 410128, China

[Xiao-Feng Zheng] College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. xiaofengzheng125@hotmail.com

[Xiao-Feng Zheng] Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, 410128, China. xiaofengzheng125@hotmail.com

[Zhao-Ying Liu] College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. liu_zhaoying@hunau.edu.cn

通讯机构：

[Xiao-Feng Zheng; Zhao-Ying Liu] C

College of Veterinary Medicine, Hunan Agricultural University, Changsha, China<&wdkj&>Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, China<&wdkj&>College of Veterinary Medicine, Hunan Agricultural University, Changsha, China<&wdkj&>Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, China

语种：

英文

关键词：

Gelsemium;Gelsenicine;Glycine;Excitotoxicity;NMDA receptors

期刊：

BMC Medicine

ISSN：

1741-7015

年：

2025

卷：

期：

页码：

1-23

DOI：

10.1186/s12916-025-03984-5

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant No. 32373072). Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province.

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

BACKGROUND: Gelsemium elegans (G. elegans) is widely recognized as one of the most toxic plants globally, particularly harmful to humans. Some reports indicate that it is non-toxic to pigs and even has a growth-promoting effect; however, the underlying reasons for this paradox remain unclear. METHODS: Gelsenicine is the main toxic component of G. elegans. This study characterized gelsenicine-induced toxicity using electrophysiological recordings, molecular dynamic simulations, c-Fos immunostaining, and multi-omics technologies. Additionally, we conducted a comprehensive analysis comparing the ...

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Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse

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