Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Chong-Yin;Zuo, Meng-Ting;Qi, Xue-Jia;Gong, Meng-Die;Xu, Wen-Bo;...

通讯作者：

Zheng, Xiao-Feng;Liu, ZY

作者机构：

[Zheng, Xiao-Feng; Qi, Xue-Jia; Gong, Meng-Die; Long, Jiang-Yu; Xu, Wen-Bo; Huang, Chong-Yin; Sun, Zhi-Liang; Liu, Zhao-Ying; Li, Pi-Shun; Meng, Si-Yu; Zuo, Meng-Ting] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

通讯机构：

[Zheng, XF; Liu, ZY ] H

Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Peoples R China.

语种：

英文

关键词：

Gelsemium;Gelsenicine;Glycine;Excitotoxicity;NMDA receptors

期刊：

BMC Medicine

ISSN：

1741-7015

年：

2025

卷：

期：

页码：

1-23

DOI：

10.1186/s12916-025-03984-5

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant No. 32373072). Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province.

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

BACKGROUND: Gelsemium elegans (G. elegans) is widely recognized as one of the most toxic plants globally, particularly harmful to humans. Some reports indicate that it is non-toxic to pigs and even has a growth-promoting effect; however, the underlying reasons for this paradox remain unclear. METHODS: Gelsenicine is the main toxic component of G. elegans. This study characterized gelsenicine-induced toxicity using electrophysiological recordings, molecular dynamic simulations, c-Fos immunostaining, and multi-omics technologies. Additionally, we conducted a comprehensive analysis comparing the ...

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Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse

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