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Effects of long-term administration of theasinensin A on healthy C57BL/6J mice: Enhancing the function of epididymal white adipose tissue and regulating the colonic microenvironment

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成果类型:
期刊论文
作者:
Xu, Weiqi;Huang, Yujie;Tao, Sainan;Zhou, Wangting;Peng, Yujia;...
通讯作者:
Zeng, Xiaoxiong(zengxx@njau.edu.cn)
作者机构:
[Chen, Guijie; Huang, Yujie; Xu, Weiqi; Tao, Sainan; Peng, Yujia; Zeng, Xiaoxiong; Kan, Xuhui; Zhou, Wangting; Dong, Wei] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.
[Liu, Zhonghua] Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Peoples R China.
[Liu, Zhonghua] Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Peoples R China.
通讯机构:
[Zeng, X.] C
College of Food Science and Technology, Jiangsu, China
语种:
英文
关键词:
Adipocytic function;Akkermansia muciniphila;Intestinal microbiota;Tea;Theasinensin A
期刊:
Food Chemistry
ISSN:
0308-8146
年:
2023
卷:
403
基金类别:
The study was supported by the Key Technology R&D Program of Jiangsu Province (No. BE2020341) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.
机构署名:
本校为其他机构
院系归属:
园艺园林学院
摘要:
The effects of theasinensin A (TSA) on healthy C57BL/6J mice were investigated. Results showed that long-term administration of 100 mg/kg body weight/day TSA might be non-toxic to healthy mice based on the unaltered basal biochemical indicators related to glucose and lipid metabolism, inflammatory factors and hepatic injury. On the contrary, TSA stimulated the rate of lipid turnover and browning of white adipose tissues, accelerated the adipocytic energy mobilization, and then reduced the white adipocytic size, ultimately enhancing resistance t...

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