Dynamics of Nrf2 and Keap1 in ARE-Mediated NQO1 Expression by Wasabi 6-(Methylsulfinyl)hexyl Isothiocyanate

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成果类型：

期刊论文

作者：

Hou, De-Xing*;Korenori, Yoshimi;Tanigawa, Shunsuke;Yamada-Kato, Tomoe;Nagai, Masashi;...

通讯作者：

Hou, De-Xing

作者机构：

[He, Xi; Hou, De-Xing; He, Jianhua] Hunan Agr Univ, Engn Res Ctr Feed Safety & Efficient Utilizat, Educ Minist, Changsha 410128, Hunan, Peoples R China.

[Korenori, Yoshimi; Hou, De-Xing; Tanigawa, Shunsuke] Kagoshima Univ, Course Biochem Sci & Technol, United Grad Sch Agr Sci, Kagoshima 8900065, Japan.

[Hou, De-Xing] Kagoshima Univ, Dept Biochem Sci & Technol, Fac Agr, Kagoshima 8900065, Japan.

[Yamada-Kato, Tomoe; Nagai, Masashi] Kinjirushi Co Ltd, Nakagawa Ku, Nagoya, Aichi 4548526, Japan.

通讯机构：

[Hou, De-Xing] H

Hunan Agr Univ, Engn Res Ctr Feed Safety & Efficient Utilizat, Educ Minist, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

6-MSITC;NQO1;Nrf2;Keap1;ubiquitination;modification

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2011

卷：

期：

页码：

11975-11982

DOI：

10.1021/jf2032439

基金类别：

Kagoshima University; Hunan Agriculture University

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a bioactive ingredient present in wasabi, a popular pungent spice in Japan. Previous studies have revealed the cytoprotective and cancer chemopreventive effects of 6-MSITC. This study aims to clarify the molecular mechanisms by investigating the action of 6-MSITC on the Nrf2/Keap1 system. 6-MSITC up-regulated the expression of NAD(P)H:quinone oxidoreductase 1 (NQO1) by increasing the Nrf2 level. Treatment with 6-MSITC extended the half-life (t1/2) of Nrf2 protein from 11.5 to 35.2 min, approximately three times longer. Moreover, 6-MSITC suppr...

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Dynamics of Nrf2 and Keap1 in ARE-Mediated NQO1 Expression by Wasabi 6-(Methylsulfinyl)hexyl Isothiocyanate

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