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Mathematical modeling of HIV-like particle assembly in vitro

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成果类型:
期刊论文
作者:
Liu, Yuewu;Zou, Xiufen*
通讯作者:
Zou, Xiufen
作者机构:
[Zou, Xiufen; Liu, Yuewu] Wuhan Univ, Sch Math & Stat, Computat Sci Hubei Key Lab, Wuhan 430072, Peoples R China.
[Liu, Yuewu] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Zou, Xiufen] W
Wuhan Univ, Sch Math & Stat, Computat Sci Hubei Key Lab, Wuhan 430072, Peoples R China.
语种:
英文
关键词:
Assembly;Computational geometry;Dynamics;Equilibrium constants;Geometry;Mathematical models;Rate constants;Recombinant proteins;Computational costs;Concentration variation;Existence and uniqueness;Initial concentration;Mathematical analysis;Particle assemblies;Positive equilibrium;Spherical particle;Nonlinear equations;geometry;human immunodeficiency virus;numerical model;protein;chemical binding;disease model;geometry;Human immunodeficiency virus;in vitro study;mathematical analysis;nonhuman;rate constant;statistical model;biological model;chemistry;growth, development and aging;Human immunodeficiency virus 1;virus assembly;Human immunodeficiency virus 1;HIV-1;Models, Biological;Virus Assembly
期刊:
Mathematical Biosciences
ISSN:
0025-5564
年:
2017
卷:
288
页码:
46-51
基金类别:
The authors thank the anonymous reviewers for their helpful comments and suggestions. This work was supported by the Major Research Plan of the National Natural Science Foundation of China (No. 91530320) and the Chinese National Natural Science Foundation (No. 61672388).
机构署名:
本校为其他机构
院系归属:
理学院
摘要:
In vitro, the recombinant HIV-1 Gag protein can generate spherical particles with a diameter of 25–30nm in a fully defined system. It has approximately 80 building blocks, and its intermediates for assembly are abundant in geometry. Accordingly, there are a large number of nonlinear equations in the classical model. Therefore, it is difficult to compute values of geometry parameters for intermediates and make the mathematical analysis using the model. In this work, we develop a new model of HIV-like particle assembly in vitro by using six-fold...

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