This paper summarizes the experiences from the exploration and practice of comprehensive reform of Applied Chemistry Specialty of Hunan Agricultural University. Taking professional talent training mode reform as an opportunity, some attempt on how to highlight characteristics of Applied Chemistry Specialty has been done, including adjustment of orientation of talent cultivation, revise of talent training scheme, reform of the personnel training mode, Fine-tuning of the professional caliber, setting-up of three professional directions, building of Vein-type curriculum system. As a result, a mor...