AbstractTumor necrosis factor receptor‐associated factor (TRAF) proteins are conserved in higher eukaryotes and play key roles in transducing cellular signals across different organelles. They are characterized by their C‐terminal region (TRAF‐C domain) containing seven to eight anti‐parallel β‐sheets, also known as the meprin and TRAF‐C homology (MATH) domain. Over the past few decades, significant progress has been made toward understanding the diverse roles of TRAF proteins in mammals and plants. Compared to other eukaryotic species, ...
