Systemic acquired resistance(SAR) is a long-lasting broad-spectrum resistance at the whole plant level activated by the primary infection of pathogenic microorganisms at local leaves. The signals generated rapidly at the initial infection site can be transmitted to other parts of the plant through the phloem to activate SAR. Pipecolic acid(Pip) and N-hydroxy-pipecolic acid(NHP), as newly discovered mobile signal molecules, play important roles in SAR signaling pathway. Here, we mainly review the latest research progress in the synth...