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The Rice Dynamin-Related Protein OsDRP1E Negatively Regulates Programmed Cell Death by Controlling the Release of Cytochrome c from Mitochondria

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成果类型:
期刊论文
作者:
Li, Zhiqiang;Ding, Bo*;Zhou, Xueping;Wang, Guo-Liang
通讯作者:
Ding, Bo
作者机构:
[Wang, Guo-Liang; Li, Zhiqiang; Ding, Bo; Zhou, Xueping] Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing, Peoples R China.
[Wang, Guo-Liang; Li, Zhiqiang] Hunan Agr Univ, Southern Reg Collaborat Innovat Ctr Grain & Oil C, Changsha, Hunan, Peoples R China.
[Wang, Guo-Liang; Li, Zhiqiang] Hunan Agr Univ, Coll Agron, Changsha, Hunan, Peoples R China.
[Wang, Guo-Liang] Ohio State Univ, Dept Plant Pathol, Columbus, OH 43210 USA.
通讯机构:
[Ding, Bo] C
Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing, Peoples R China.
语种:
英文
关键词:
Mitochondria;Leaves;Rice;Guanosine triphosphatase;Point mutation;Cell death;Rice blast fungus;Apoptosis
期刊:
PLOS Pathogens
ISSN:
1553-7366
年:
2017
卷:
13
期:
1
页码:
e1006157
基金类别:
This work was funded by a grant from the National Natural Science Foundation of China to BD (31371928). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to thank Mrs. Maria Bellizzi for her excellent help in the greenhouse.
机构署名:
本校为其他机构
院系归属:
农学院
植物保护学院
摘要:
Programmed cell death (PCD) mediated by mitochondrial processes has emerged as an important mechanism for plant development and responses to abiotic and biotic stresses. However, the role of translocation of cytochrome c from the mitochondria to the cytosol during PCD remains unclear. Here, we demonstrate that the rice dynamin-related protein 1E (OsDRP1E) negatively regulates PCD by controlling mitochondrial structure and cytochrome c release. We used a map-based cloning strategy to isolate OsDRP1E from the lesion mimic mutant dj-lm and confirm...

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