CD96, a new immune checkpoint, correlates with immune profile and clinical outcome of glioma

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成果类型：

期刊论文

作者：

Liu, Fangkun;Huang, Jing;He, Fengqiong;Ma, Xiaodong;Fan, Fan;...

通讯作者：

Zhang, Liyang

作者机构：

[He, Fengqiong; Fan, Fan; Zhuo, Yang; Liu, Fangkun; Zhang, Liyang; Meng, Ming] Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[He, Fengqiong; Fan, Fan; Zhuo, Yang; Liu, Fangkun; Zhang, Liyang; Meng, Ming] Cent South Univ, Xiangya Hosp, Clin Diag & Therapy Ctr Glioma, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

[Huang, Jing] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.

[Huang, Jing] Cent South Univ, Chinese Natl Clin Res Ctr Mental Disorders Xiangy, Chinese Natl Technol Inst Mental Disorders,Xiangy, Hunan Key Lab Psychiat & Mental Hlth,Mental Hlth, Changsha 410011, Hunan, Peoples R China.

[Ma, Xiaodong] Hunan Agr Univ, Orient Sci & Technol Coll, Training & Exchange Cooperat Ctr, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Zhang, Liyang] C

Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp, Clin Diag & Therapy Ctr Glioma, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2020

卷：

期：

页码：

10768

DOI：

10.1038/s41598-020-66806-z

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81402249]; Xiangya Hospital Youth Found [2018Q02]

机构署名：

本校为其他机构

院系归属：

东方科技学院

摘要：

CD96 is a promising candidate for immunotherapy. However, its role and importance in glioma remains unknown. We thus aimed to genetically and clinically characterize CD96 expression in gliomas. For this, we extracted RNA-seq data of 699 glioma samples from the TCGA dataset and validated these findings using the CGGA dataset comprising 325 glioma samples. Clinical and isocitrate dehydrogenase (IDH) mutation status were also analyzed. Various packages in R language were mainly used for statistical analysis. CD96 expression was significantly up-regulated in high-grade, IDH-wildtype, and mesenchym...

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CD96, a new immune checkpoint, correlates with immune profile and clinical outcome of glioma

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