Immune-modulatory effects and mechanism of action of l-theanine on ETEC-induced immune-stressed mice via nucleotide-binding oligomerization domain-like receptor signaling pathway

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成果类型：

期刊论文

作者：

Gong, Zhihua;Lin, Ling;Liu, Zunying;Zhang, Sheng;Liu, An;...

通讯作者：

Deng, Yanli;Xiao, Wenjun

作者机构：

[Gong, Zhihua; Liu, Zunying; Liu, An; Xiao, Wenjun; Zhang, Sheng; Deng, Yanli; Xiao, WJ; Liu, Qiuling; Lin, Ling; Chen, Ling] Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

[Gong, Zhihua; Liu, Zunying; Liu, An; Xiao, Wenjun; Zhang, Sheng; Deng, Yanli; Xiao, WJ; Liu, Qiuling; Lin, Ling; Chen, Ling] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China.

[Gong, Zhihua; Liu, Zunying; Liu, An; Xiao, Wenjun; Zhang, Sheng; Deng, Yanli; Xiao, WJ; Liu, Qiuling; Lin, Ling; Chen, Ling] Hunan Agr Univ, Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China.

[Deng, Yanli] Guizhou Univ, Tea Coll, Guiyang 550025, Guizhou, Peoples R China.

通讯机构：

[Deng, YL; Xiao, WJ] H

Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

L-Theanine;Immune stress;Innate immunity;Nucleotide-binding oligomerization domain-like receptor;Immune mechanism

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2019

卷：

页码：

32-40

DOI：

10.1016/j.jff.2019.01.011

基金类别：

National Key Research and Development Program of China [2017YFD0400803]; Science and Technology Major Project of Hunan Province, China [2017NK1020]; Science and Technology Major Project of Changsha, China [kq1804003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31871804]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

L-Theanine (LTA), a non-protein-derived amino acid, is widely used as a functional ingredient. Here, we established an immune-stressed mouse model by infecting mice with enterotoxigenic Escherichia coli (ETEC) to study the immunomodulatory effects of LTA with respect to nucleotide-binding oligomerization domain (NOD)-like receptor signaling in vivo. Compared to ETEC control group, LTA alleviated ileal tissue lesions, significantly attenuated interleukin-1 beta (IL-1 beta) and tumor necrosis alpha (TNF alpha) overexpression, which was consistent with their protein levels. Additionally, LTA inhi...

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Immune-modulatory effects and mechanism of action of l-theanine on ETEC-induced immune-stressed mice via nucleotide-binding oligomerization domain-like receptor signaling pathway

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