Immune-modulatory effects and mechanism of action of l-theanine on ETEC-induced immune-stressed mice via nucleotide-binding oligomerization domain-like receptor signaling pathway

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成果类型：

期刊论文

作者：

Gong, Zhihua;Lin, Ling;Liu, Zunying;Zhang, Sheng;Liu, An;...

通讯作者：

Deng, Yanli;Xiao, Wenjun

作者机构：

[Gong, Zhihua; Liu, Zunying; Liu, An; Xiao, Wenjun; Zhang, Sheng; Deng, Yanli; Xiao, WJ; Liu, Qiuling; Lin, Ling; Chen, Ling] Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

[Gong, Zhihua; Liu, Zunying; Liu, An; Xiao, Wenjun; Zhang, Sheng; Deng, Yanli; Xiao, WJ; Liu, Qiuling; Lin, Ling; Chen, Ling] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China.

[Gong, Zhihua; Liu, Zunying; Liu, An; Xiao, Wenjun; Zhang, Sheng; Deng, Yanli; Xiao, WJ; Liu, Qiuling; Lin, Ling; Chen, Ling] Hunan Agr Univ, Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China.

[Deng, Yanli] Guizhou Univ, Tea Coll, Guiyang 550025, Guizhou, Peoples R China.

通讯机构：

[Deng, YL; Xiao, WJ] H

Hunan Agr Univ, Minist Educ, Key Lab Tea Sci, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

L-Theanine;Immune stress;Innate immunity;Nucleotide-binding oligomerization domain-like receptor;Immune mechanism

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2019

卷：

页码：

32-40

DOI：

10.1016/j.jff.2019.01.011

基金类别：

This work was financially supported by The National Key Research and Development Program of China (grant number 2017YFD0400803 ), Science and Technology Major Project of Hunan Province, China (grant number 2017NK1020 ), Science and Technology Major Project of Changsha, China (grant number kq1804003 ), and The National Natural Science Foundation of China (grant number 31871804 ).

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

L-Theanine (LTA), a non-protein-derived amino acid, is widely used as a functional ingredient. Here, we established an immune-stressed mouse model by infecting mice with enterotoxigenic Escherichia coli (ETEC) to study the immunomodulatory effects of LTA with respect to nucleotide-binding oligomerization domain (NOD)-like receptor signaling in vivo. Compared to ETEC control group, LTA alleviated ileal tissue lesions, significantly attenuated interleukin-1 beta (IL-1β) and tumor necrosis alpha (TNFα) overexpression, which was consistent with t...

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Immune-modulatory effects and mechanism of action of l-theanine on ETEC-induced immune-stressed mice via nucleotide-binding oligomerization domain-like receptor signaling pathway

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