Effects of quercetin on proliferation and H2O2-induced apoptosis of intestinal porcine enterocyte cells

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成果类型：

期刊论文

作者：

Chen, Zhigang;Yuan, Qiaoling;Xu, Guangren;Chen, Huiyu;Lei, Hongyu;...

通讯作者：

Su, Jianming

作者机构：

[Chen, Zhigang; Xu, Guangren; Yuan, Qiaoling; Su, Jianming] Hunan Agr Univ, Coll Vet Med, Dept Basic Vet Med, Changsha 410128, Hunan, Peoples R China.

[Lei, Hongyu; Chen, Huiyu] Hunan Agr Univ, Coll Vet Med, Dept Prevent Vet Med, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Su, Jianming] H

Hunan Agr Univ, Coll Vet Med, Dept Basic Vet Med, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

hydrogen peroxide;quercetin;reactive oxygen metabolite;animal;apoptosis;cell cycle;cell line;cell proliferation;cell survival;cytology;drug effect;gene expression regulation;genetics;intestine cell;intestine mucosa;lipid peroxidation;metabolism;mitochondrial membrane potential;oxidation reduction reaction;oxidative stress;pig;Animals;Apoptosis;Cell Cycle;Cell Line;Cell Proliferation;Cell Survival;Enterocytes;Gene Expression Regulation;Hydrogen Peroxide;Intestinal Mucosa;Lipid Peroxidation;Membrane Potential, Mitochondrial;Oxidation-Reduction;Oxidative Stress;Quercetin;Reactive Oxygen Species;Swine

期刊：

Molecules

ISSN：

1420-3049

年：

2018

卷：

期：

页码：

2012

DOI：

10.3390/molecules23082012

基金类别：

Hunan Provincial Innovation Foundation for Postgraduate [CX2015B257]; 2011 Collaborative Innovation Center of Hunan Province for Livestock Safety Production

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Weanling stress and toxicosis, which are harmful to the health of pigs' intestines, are associated with oxidative stress. Quercetin (Que) is a polyphenolic compound that shows good anti-cancer, anti-inflammation and anti-oxidation effects. This study aimed to elaborate whether or not Que promotes IPEC-J2 (intestinal porcine enterocyte cells) proliferation and protects IPEC-J2 from oxidative damage. Thus, we examined the effects of Que on proliferation and H2O2-induced apoptosis in IPEC-J2. The results showed that Que increased IPEC-J2 viabililt...

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Effects of quercetin on proliferation and H2O2-induced apoptosis of intestinal porcine enterocyte cells

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