Dissection the endocytic routes of viral capsid proteins-coated upconversion nanoparticles by single-particle tracking

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成果类型：

期刊论文

作者：

Ning, Yujun;Wei, Lin;Lin, Shen;Jiang, Yifan;Wang, Naidong;...

通讯作者：

Naidong Wang<&wdkj&>Lehui Xiao

作者机构：

[Ning, Yujun] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China.

[Ning, Yujun; Xiao, Lehui; Lin, Shen] Nankai Univ, Coll Chem, State Key Lab Med Chem Biol, Tianjin Key Lab Biosensing & Mol Recognit, Tianjin 300071, Peoples R China.

[Wei, Lin] Hunan Normal Univ, Coll Chem & Chem Engn, Changsha 410081, Peoples R China.

[Wang, Naidong; Jiang, Yifan] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Jiang, Yifan] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China.

通讯机构：

[Naidong Wang] C

[Lehui Xiao] S

College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China<&wdkj&>State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, China

语种：

英文

关键词：

Upconversion nanoparticles;Viral capsid proteins;Single-particle tracking;Hepatoma cells;Endocytosis

期刊：

中国化学快报：英文版

ISSN：

1001-8417

年：

2022

卷：

期：

页码：

4710-4714

DOI：

10.1016/j.cclet.2021.12.084

基金类别：

financial support from the National Natural Science Foundation of China （Nos. 22174079, 21974073）；

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Real-time exploring the cellular endocytic pathway of viral capsid proteins (VCPs) functionalized nanocargos at the single-particle level can provide deep insight into the kinetic information involved in virus infection. In this work, porcine circovirus type 2 (PCV2) VCPs with different functions are modified onto the surface of upconversion nanoparticles (VCPs-UCNPs) to investigate the cellular internalization process in real-time. Clathrin-mediated endocytosis is found to be the essential uptake mechanism for these VCPs-UCNPs. Besides, it is verified that P-1-UCNPs (PCV2 VCPs with nuclear lo...

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Dissection the endocytic routes of viral capsid proteins-coated upconversion nanoparticles by single-particle tracking

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