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Protopine Alleviates Dextran Sodium Sulfate-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Regulating Intestinal Microbiota

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成果类型:
期刊论文
作者:
Yue, Meishan;Huang, Jialu;Ma, Xiaolan;Huang, Peng;Liu, Yisong;...
通讯作者:
Zeng, JG
作者机构:
[Ma, Xiaolan; Yue, Meishan; Huang, Jialu; Zeng, Jianguo] Shanxi Agr Univ, Coll Vet Med, Jinzhong 030801, Peoples R China.
[Liu, Yisong; Zeng, Jianguo; Huang, Peng] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.
通讯机构:
[Zeng, JG ] S
Shanxi Agr Univ, Coll Vet Med, Jinzhong 030801, Peoples R China.
Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.
语种:
英文
关键词:
protopine;ulcerative colitis;intestinal microbiota;intestinal mucosal barrier
期刊:
Molecules
ISSN:
1420-3049
年:
2023
卷:
28
期:
13
页码:
5277-
基金类别:
Conceptualization, M.Y.; Formal analysis, M.Y. and J.H.; Funding acquisition, J.Z.; Investigation, X.M.; Methodology, M.Y. and J.H.; Project administration, J.Z.; Software, M.Y. and X.M.; Supervision, J.Z.; Validation, J.H.; Visualization, M.Y.; Writing—original draft, M.Y.; Writing—review and editing, P.H., Y.L. and J.Z. All authors have read and agreed to the published version of the manuscript. This research was funded by the National Key Research and Development Program (2022YFD1801101).
机构署名:
本校为通讯机构
院系归属:
动物医学院
摘要:
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD), and its pathogenesis is related to intestinal mucosal barrier damage and gut microbiota imbalance. Protopine (PRO), an isoquinoline alkaloid, is one of the main anti-inflammatory ingredients of traditional Chinese medicine Macleaya cordata (Willd.) R. Br. This study investigated the effects of PRO on the intestinal mucosal barrier and gut microbiota in dextran sodium sulfate (DSS)-induced colitis mice. C57BL/6J mice were treated with 3% DSS in drinking water to induce acute colitis, while PRO was administered orally once daily for...

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