Antibiotics-induced perturbations in gut microbial diversity influence metabolic phenotypes in a murine model of high-fat diet-induced obesity

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成果类型：

期刊论文

作者：

Liu, Dongmin;Wen, Beibei;Zhu, Kun;Luo, Yong;Li, Juan;...

通讯作者：

Huang, Jianan;Liu, Zhonghua

作者机构：

[Wen, Beibei; Li, Yinhua; Huang, Jianan; Liu, Zhonghua; Liu, Dongmin; Lin, Haiyan; Luo, Yong; Li, Juan; Zhu, Kun] Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Hunan, Peoples R China.

[Liu, Dongmin] Hunan Univ Sci & Engn, Yongzhou 425199, Peoples R China.

[Li, Yinhua; Huang, Jianan; Liu, Zhonghua; Lin, Haiyan; Li, Juan] Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China.

[Li, Yinhua; Huang, Jianan; Liu, Zhonghua; Lin, Haiyan; Li, Juan] Collaborat Innovat Ctr Utilizat Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Huang, JA; Liu, ZH] H

[Huang, JA; Liu, ZH] N

[Huang, JA; Liu, ZH] C

Hunan Agr Univ, Minist Educ Tea Sci, Key Lab, Changsha 410128, Hunan, Peoples R China.

Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Antibiotics;Gut microbiota;HFD (high fat diet);Metabolic phenotype;Obesity

期刊：

Applied Microbiology and Biotechnology

ISSN：

0175-7598

年：

2019

卷：

103

期：

页码：

5269-5283

DOI：

10.1007/s00253-019-09764-5

基金类别：

Funding The authors wish to thank the Key Laboratory of Ministry of Education for Tea Science in China and the National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients in China for their financial support. This study was supported by the National Major R & D Project in China (2017YFD0400803) and China Tea Research System Project (CARS19-09B).

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

Gut microbiota play a key role in the regulation of obesity and associated metabolic disorders. To study the relationship between them, antibiotics have been widely used to generate pseudo-germ-free rodents as control models. However, it is not clear whether antibiotics impact an animal's metabolic phenotype. Therefore, the effect of antibiotics-induced gut microbial perturbations on metabolic phenotypes in high-fat diet (HFD) fed mice was investigated. The results showed that antibiotics perturbed gut microbial composition and structure. Community diversity and richness were reduced, and the ...

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Antibiotics-induced perturbations in gut microbial diversity influence metabolic phenotypes in a murine model of high-fat diet-induced obesity

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