期刊论文

中文

生物化工

2096-0387

2023

9

02

96-101

10.3969/j.issn.2096-0387.2023.02.021

本校为第一机构

目的：筛选灵芝改善Ⅱ型糖尿病关键成分、通路以及靶点。方法：基于GEO数据库中4个Ⅱ型糖尿病相关芯片分析结果，以及GeneCards和CTD数据库筛选结果，得到疾病靶点；使用TCMSP、HERB、ETCM和Batman-TCM数据库检索灵芝相关靶点，进而与疾病靶点取交集，得到共同靶点；将共同靶点及其相应的活性成分构建网络关系。结果：Lucialdehyde C、Lucidumol A、Ganodermanondiol、Ganoderiol F和Ganoderan B可能为灵芝改善Ⅱ型糖尿病的主要活性成分；cAMP通路、MAPK通路、C型凝集素样受体通路、AMPK通路以及胰岛素通路可能是灵芝改善Ⅱ型糖尿病的关键通路；MAPK3、PIK3CA、RELA、CALM1、INS、IL1B以及PTGS2...

Objective:To screen the key components,pathways and targets of Ganoderma lucidum to improve typeⅡdiabetes.Methods:Based on the analysis results of four typeⅡdiabetes related chips in the GEO database,as well as the screening results of GeneCards and CTD databases,diseas...MORE Objective:To screen the key components,pathways and targets of Ganoderma lucidum to improve typeⅡdiabetes.Methods:Based on the analysis results of four typeⅡdiabetes related chips in the GEO database,as well as the screening results of GeneCards and CTD databases,dise...