期刊论文

中文

中华行为医学与脑科学杂志

1674-6554

2015

24

5

397-401

10.3760/cma.j.issn.1674-6554.2015.05.004

国家自然科学基金项目（30900484） 天津市卫生局重点课题（2010KR10）

本校为第一机构

目的探讨度洛西汀对抑郁模型大鼠行为及海马S100B和信号通路ERKl/2-NF-κB表达的影响。方法选取慢性轻度不可预知应激刺激法制备50只抑郁症模型大鼠,将其随机分为非干预组(B组,n=10)、不同用药时间的度洛西汀干预组C、D、E和F组,每组各10只。10只健康大鼠为对照组(A组)。各组灌胃:A组和B组(生理盐水28d),C组(生理盐水27d+度洛西汀1d)、D组(生理盐水21d+度洛西汀7d)、E组(生理盐水14d+度洛西汀14d)和F组(度洛西汀28d)〕。灌胃结束,应用旷场试验、糖水偏爱试验检测大鼠行为改变;Western blot检测各组海马S100B、ERKl/2及NF-KB的表达。结果E和F组大鼠干预28d后旷场试验水平得分、垂直运动得分与潜伏...

Objective To analyze the effect of duloxetine on S100B and signal pathway ERK1/2-NF-κB expression in hippocampus in depression rat.Methods Chronic unpredictable mild stimulation was used to establish depressive model rats (n=50).They were randomly divided into no-intervention group (n=10),different treatment time of duloxetine group (C,D,E,F group,10 rats in each group)and then 10 normal rats were selected as control group.Behavior tests including open-field test and the saccharine preference test were used to test the behavioral change of rat...