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Maternal antibiotic treatment during pregnancy attenuates the transport and absorption of maternal antibody IgG through TLR4 and TLR2 receptor

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成果类型:
期刊论文
作者:
Ding, Yanan;Yao, Xiaofeng;Zhang, Haihan;He, Xi;Song, Zehe
作者机构:
[Song, Zehe; Ding, Yanan; He, Xi; Yao, Xiaofeng; Zhang, Haihan] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China.
语种:
英文
关键词:
Gut Microbiota;antibiotic;Toll like receptor;IgG transport;IgG absorption
期刊:
Frontiers in Microbiology
ISSN:
1664-302X
年:
2023
卷:
14
页码:
1109273
基金类别:
The authors are thankful to the Project supported by the National Natural ScienceFoundation of China (Grant No: 31902171).
机构署名:
本校为第一机构
院系归属:
动物科学技术学院
摘要:
Maternal antibody IgG, the main antibody in colostrum, plays an important role in neonates protection. Commensal microbiota is closely related to host antibody repertoire. However, there are few reports on how maternal gut microbiota affects maternal antibody IgG transfer. In the present study, we investigated the effects of altering the gut microbiota (treated with antibiotics during pregnancy) on maternal IgG transportation and offspring absorption and explored its underlying mechanisms. Results showed that antibiotic treatment during pregnan...

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