期刊论文

Liu, X.-X.

中文

中国抗生素杂志

1001-8689

2012

37

12

952-955

10.3969/j.issn.1001-8689.2012.12.014

科学技术部专项经费—国际(日本)科技合作项目 科学技术部专项经费—国际(日本)科技合作项目

本校为第一且通讯机构

目的测定β-内酰胺类药物单用及与复方黄连注射液联合使用对金黄色葡萄球菌ATCC29213的MIC和MPC,探讨β-内酰胺类与复方黄连注射液联合使用对耐药突变选择窗(MSW)的影响,为临床优化抗菌药物给药方案,限制耐药突变体选择性扩增提供一条新思路。方法采用MH琼脂二倍稀释法测定阿莫西林和头孢噻呋、复方黄连注射液单独用药和联合用药的最低抑菌浓度(MIC)、抑制99%接种细菌生长的最低抑菌浓度(MIC_(99))、防突变浓度(MPC)。结果阿莫西林单独使用时的SI(MPC/MIC_(99))值为15.2,与16MIC的复方黄连注射液联合使用后,SI降低至5.1,为其单独用药的1/3;头孢噻呋单独使用时其SI值为16.1,与16MIC的复方黄连注射...

Objective: To determine MIC and MPC of Staphylococcus aureus 29213 to β-lactam drugs or mixture of and β-lactam drugs with compound coptis injection, investigate the effect of β-lactam combined with compound coptis injection for drug-resistant mutant selection window (MSW) and provide a new idea for optimizing regimen of antibiotics and restricting selective amplification of resistant mutants. Methods: The MIC, MIC99 and MPC of amoxicillin or ceftiofur or compound coptis injection single-used as well as mixture of amoxicillin with compound c...