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Modulation of Acute Intestinal Inflammation by Dandelion Polysaccharides: An In-Depth Analysis of Antioxidative, Anti-Inflammatory Effects and Gut Microbiota Regulation

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成果类型:
期刊论文
作者:
Li, Zhu;Li, Xinyao;Shi, Panpan;Li, Pingping;Fu, Yue;...
通讯作者:
Huang, P;Zeng, JG
作者机构:
[Fu, Yue; Zhou, Junjuan; Li, Zhu; Huang, P; Li, Pingping; Tan, Guifeng; Huang, Peng; Shi, Panpan] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
[Li, Xinyao] Hunan Agr Univ, Hunan Key Lab Tradit Chinese Vet Med, Changsha 410128, Peoples R China.
[Zeng, Jianguo] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.
通讯机构:
[Zeng, JG ; Huang, P ] H
Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.
语种:
英文
关键词:
dandelion polysaccharides;intestinal inflammation;gut microbiota;16S rRNA;LPS
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2024
卷:
25
期:
3
页码:
1429-
基金类别:
This work was supported by the National Key R&D Program of China (2023YFD1301200), the Science and Technology Innovation Program of Hunan Province (2021RC3091) and the Hunan Provincial Natural Science Foundation of China (2021JJ20032).
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
动物医学院
摘要:
Acute colitis is a complex disease that can lead to dysregulation of the gut flora, inducing more complex parenteral diseases. Dandelion polysaccharides (DPSs) may have potential preventive and therapeutic effects on enteritis. In this study, LPS was used to induce enteritis and VC was used as a positive drug control to explore the preventive and therapeutic effects of DPS on enteritis. The results showed that DPS could repair the intestinal barrier, down-regulate the expression of TNF-α, IL-6, IL-1β, and other pro-inflammatory factors, up-re...

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