版权说明 操作指南
首页 > 成果 > 详情

Super RNA Pol II domains enhance minor ZGA through 3D interaction to ensure the integrity of major transcriptional waves in late-ZGA mammals

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Zhang, Jingcheng;Li, Hengkuan;Li, Linmi;Wu, Jie;Song, Linjie;...
通讯作者:
Zhao, Shuhong;Ren, Gang;Zhao, Yunxia;Zhang, Yong
作者机构:
[Liu, Zixiao; Dong, Zhenyu; Li, Linmi; Li, Hengkuan; Ren, Gang; Zhang, Jingcheng; Wang, Yong; Wang, Debao; Zhang, Hexu; Li, Wenying; Wu, Jie; Jiao, Mei; Shi, Binqiang; Song, Linjie] Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling 712100, China
[Li, Linmi] Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
[Song, Linjie] College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
[Zhao, Shuhong; Zhao, Yunxia; Liu, Xin; Hu, Mingyang] Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
[Pan, Zhangyuan] Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
通讯机构:
[Zhao, Yunxia; Zhao, Shuhong] Y
[Ren, Gang] C
[Zhang, Yong] K
Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling 712100, China<&wdkj&>College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China<&wdkj&>Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China<&wdkj&>Yazhouwan National Laboratory, 8 Huanjin Road, Yazhou District, Sanya City, Hainan Province 572024, China
语种:
英文
关键词:
3D interaction;RNA Pol II;SPDs;ZGA pace;interspecies comparison;zygotic genome activation
期刊:
Cell Genomics
ISSN:
2666-979X
年:
2025
页码:
100856
机构署名:
本校为其他机构
院系归属:
动物医学院
摘要:
Zygotic genome activation (ZGA) occurs at distinct stages across mammals, with mice initiating ZGA at the 2-cell stage and bovines and humans activating the process in the 4- to 8-cell stages. RNA polymerase II (RNA Pol II) gradually initiates ZGA in mice, but regulation in late-ZGA species remains unclear. Here, RNA Pol II profiling in bovine embryos identified strong intergenic clusters that boost minor ZGA gene expression via chromatin interactions and are named super RNA Pol II domains (SPDs). CRISPRi perturbation of SPDs in bovine embryos decreases the expression of minor ZGA genes, where...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com