Super RNA Pol II domains enhance minor ZGA through 3D interaction to ensure the integrity of major transcriptional waves in late-ZGA mammals

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成果类型：

期刊论文

作者：

Zhang, Jingcheng;Li, Hengkuan;Li, Linmi;Wu, Jie;Song, Linjie;...

通讯作者：

Ren, Gang;Zhang, Y;Zhao, Shuhong;Zhao, YX;Ren, G

作者机构：

[Liu, Zixiao; Dong, Zhenyu; Li, Hengkuan; Ren, Gang; Wang, Yong; Zhang, Hexu; Li, Wenying; Wu, Jie; Jiao, Mei; Ren, G; Zhang, Yong; Song, Linjie; Li, Linmi; Zhang, Jingcheng; Wang, Debao; Shi, Binqiang; Hu, Mingyang] Northwest A&F Univ, Minist Agr, Key Lab Anim Biotechnol, Xianyang 712100, Peoples R China.

[Zhao, Shuhong; Zhao, Yunxia; Li, Linmi; Liu, Xin; Hu, Mingyang] Huazhong Agr Univ, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China.

[Zhao, Shuhong; Zhao, Yunxia; Li, Linmi; Liu, Xin; Hu, Mingyang] Huazhong Agr Univ, Coll Anim Sci & Technol, Key Lab Swine Genet & Breeding, Minist Agr, Wuhan 430070, Peoples R China.

[Pan, Zhangyuan] Chinese Acad Agr Sci, Inst Anim Sci, Beijing 100193, Peoples R China.

[Zhou, Chuan] Hunan Agr Univ, Coll Vet Med, Changsha 410000, Peoples R China.

通讯机构：

[Ren, G ; Ren, G; Zhang, Y ] N

[Zhao, YX ; Zhao, SH] Y

Northwest A&F Univ, Minist Agr, Key Lab Anim Biotechnol, Xianyang 712100, Peoples R China.

Yazhouwan Natl Lab, Huanjin Rd, Sanya 572024, Hainan, Peoples R China.

Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Peoples R China.

语种：

英文

关键词：

3D interaction;RNA Pol II;SPDs;ZGA pace;interspecies comparison;zygotic genome activation

期刊：

Cell Genomics

ISSN：

2666-979X

年：

2025

卷：

期：

页码：

100856

DOI：

10.1016/j.xgen.2025.100856

基金类别：

Biological Breeding-National Science and Technology Major Project [2023ZD04050]; Foundation for Innovative Research Groups of the National Natural Science Foundation of China [32221005]; Shaanxi Livestock and Poultry Breeding Double-chain Fusion Key Project [2022GD-TSLD-46]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Zygotic genome activation (ZGA) occurs at distinct stages across mammals, with mice initiating ZGA at the 2-cell stage and bovines and humans activating the process in the 4- to 8-cell stages. RNA polymerase II (RNA Pol II) gradually initiates ZGA in mice, but regulation in late-ZGA species remains unclear. Here, RNA Pol II profiling in bovine embryos identified strong intergenic clusters that boost minor ZGA gene expression via chromatin interactions and are named super RNA Pol II domains (SPDs). CRISPRi perturbation of SPDs in bovine embryos decreases the expression of minor ZGA genes, where...

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Super RNA Pol II domains enhance minor ZGA through 3D interaction to ensure the integrity of major transcriptional waves in late-ZGA mammals

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