期刊论文

Zhou, HJ;Fang, LZ;Hu, XX;Yang, N

英文

Nature Genetics

1061-4036

2025

1-11

10.1038/s41588-025-02155-9

Agriculture and Food Research Initiative Competitive from the US Department of Agriculture (USDA) National Institute of Food and Agriculture; CellFood Hub (Aarhus University Foundation, AUFF); USDA National Institute of Food and Agriculture [2022-67015-36215, 2020-67015-31175]; USDA National Institute of Food and Agriculture, Multistate Research [2022-67015-36215, 2015-67015-22940]; California Agricultural Experimental Station; National Key Research and Development Program of China [2021YFD1300600, 2022YFF1000204]; National Natural Science Foundation of China [31961133003, 32272862, 32022078, 32030021]; National Research Facility for Phenotypic and Genotypic Analysis of Model Animals (Beijing); Jiangsu Agricultural Industry Technology System [JATS[2022]406]; Local Innovative and Research Teams Project of Guangdong Province [2019BT02N630]; National Key Research and Development Program of China [2021YFF0703702, 2024YFF1000100]; Technical Support Talent Program of Chinese Academy of Sciences; Science and Technology Innovation 2030-Major Project [2022ZD04017]; Science and Technology Planning Project of Guangzhou City [201504010017]; Natural Scientific Foundation of China [31402067]; Natural Sciences and Engineering Research Council of Canada Discovery grant [RGPIN-2022-03884]; Yunnan Fundamental Research Projects [202301AW070012, 202401AV070007]; USDA NIFA AFRI [2019-67015-29321, 2021-67015-33409]; USDA Agricultural Research Service [8042-31000-112-00-D]

本校为第一机构

The chicken is a valuable model for understanding fundamental biology and vertebrate evolution and is a major global source of nutrient-dense and lean protein. Despite being the first non-mammalian amniote to have its genome sequenced, a systematic characterization of functional variation on the chicken genome remains lacking. Here, we integrated bulk RNA sequencing (RNA-seq) data from 7,015 samples, single-cell RNA-seq data from 127,598 cells and 2,869 whole-genome sequences to present a pilot atlas of regulatory variants across 28 chicken tis...