Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ2177]; Research Foundation of Hunan Provincial Education Department, China [15A086]
机构署名：
本校为第一且通讯机构
院系归属：
动物医学院
摘要：
Porcine circovirus type 2 (PCV2) causes huge economic losses in the global swine industry and has a complex and poorly understood virus-host interaction mechanism. We reported that the C-terminal of the capsid protein of all PCV2 isolates shared a strictly conserved PXXP motif that may interact with SH3 domain-containing tyrosine kinases; however, its roles in PCV2 cell entry and replication remain unknown. In this study, we determined that mRNA levels of two SH3 domain-containing tyrosine kinases family (Abl and Src) had distinct profiles (wild-type and PXXP-mutated) during PCV2 infections of...
