期刊论文

Liu, Gang;Fang, Jun

英文

Frontiers in Physiology

1664-042X

2019

10

461824

10.3389/fphys.2019.01152

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772642, 31672457]; National Key Research and Development Program of China [2016YFD0500504, 2016YFD0501201]; Ministry of Agriculture of the People's Republic of ChinaMinistry of Agriculture, China [2015-Z64, 2016-X47]; Local Science and Technology Development Project [YDZX20184300002303, 2018CT5002]; Hunan Provincial Science and Technology Department [2017NK2322, 2018TP1031, 2016NK2101, 2016WK2008, 2016TP2005, 2018WK4025]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M632963]; Double first-class construction project of Hunan Agricultural University [2019T120705, SYL201802003]

本校为第一且通讯机构

The aim of this study was to examine the effects of Lactobacillus brevis on the microbial community and serum metabolome in colitis induced by dextran sulfate sodium (DSS). ICR mice were randomly distributed into three treatment groups: (i) L. brevis treatment alone (control), (ii) DSS administration alone, and (iii) treatment with L. brevis and DSS. Our results demonstrate that L. brevis treatment significantly alleviated DSS-induced body weight loss and colon inflammation. In addition, LC-MS analysis of serum metabolites revealed that L. brevis treatment increased the serum level of metaboli...