Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex

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成果类型：

期刊论文

作者：

Xu, Gang;Xia, Zhangchuan;Deng, Feiyan;Liu, Lin;Wang, Qiming;...

通讯作者：

Liu, Shi

作者机构：

[Xu, Gang; Xia, Zhangchuan; Deng, Feiyan; Liu, Lin; Cheng, Zhikui; Zhu, Ying; Liu, Shi] Wuhan Univ, Coll Life Sci, Modern Virol Res Ctr, State Key Lab Virol, Wuhan, Hubei, Peoples R China

[Wang, Qiming] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Hunan, Peoples R China

[Yu, Yi] Zhejiang Univ, Life Sci Inst, Key Lab Biosyst Homeostasis & Protect, Minist Educ, Hangzhou, Zhejiang, Peoples R China

[Yu, Yi] Zhejiang Univ, Life Sci Inst, Innovat Ctr Cell Signaling Network, Hangzhou, Zhejiang, Peoples R China

[Wang, Fubing] Wuhan Univ, Dept Lab Med, Zhongnan Hosp, Wuhan, Hubei, Peoples R China

通讯机构：

[Liu, Shi] W

Wuhan Univ, Coll Life Sci, Modern Virol Res Ctr, State Key Lab Virol, Wuhan, Hubei, Peoples R China.

语种：

英文

关键词：

Transfection;Influenza A virus;Cytokines;Transcription factors;Reverse transcriptase-polymerase chain reaction;Vesicular stomatitis virus;Viral replication;Viral transmission and infection

期刊：

PLOS Pathogens

ISSN：

1553-7366

年：

2019

卷：

期：

页码：

e1008002

DOI：

10.1371/journal.ppat.1008002

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872262, 31500149, 31570870, 81301428, 81802627, 81601764]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2042017kf0221, 2042015kf0188]; Science and Technology Innovation Fostering Foundation of Zhongnan Hospital of Wuhan University [cxpy20160025]; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [TRR60, RTG1949]; National Mega Project on Major Infectious Diseases Prevention [2017ZX10103005-007]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

The galectin 3 binding protein (LGALS3BP, also known as 90K) is a ubiquitous multifunctional secreted glycoprotein originally identified in cancer progression. It remains unclear how 90K functions in innate immunity during viral infections. In this study, we found that viral infections resulted in elevated levels of 90K. Further studies demonstrated that 90K expression suppressed virus replication by inducing IFN and pro-inflammatory cytokine production. Upon investigating the mechanisms behind this event, we found that 90K functions as a scaff...

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Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex

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