DNA Damage and Decrease of Cellular Oxidase Activity in Piglet Sertoli Cells Exposed to Arsanilic Acid

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成果类型：

期刊论文

作者：

Zhang, Ming;He, Zuping;Yuan, Hui*;Zhu, Li;Guo, Chengzhi;...

通讯作者：

Yuan, Hui

作者机构：

[Wu, Jing; Yin, Lu; Deno, Sijun; Zhu, Li; Yuan, Liyun; Wen, Lixin; Guo, Chengzhi; Yuan, Hui; Zhang, Ming] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Zhang, Ming] Jiangxi Biotech Vocat Coll, Nanchang 330200, Jiangxi, Peoples R China.

[He, Zuping] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Med Ctr, Washington, DC 20057 USA.

[Yuan, Hui] Hunan Agr Univ, Coll Vet Med, Changsha 421008, Hunan, Peoples R China.

通讯机构：

[Yuan, Hui] H

Hunan Agr Univ, Coll Vet Med, Changsha 421008, Hunan, Peoples R China.

语种：

英文

关键词：

superoxide dismutase: SOD;EC 1.15.1.1;DNA: damage;GSH-Px;cellular oxidase;arsanilic acid: 98-50-0;toxicity;oxidative stress;cell growth;enzyme activity;food chain;enzyme digestion

期刊：

Journal of Veterinary Medical Science

ISSN：

0916-7250

年：

2011

卷：

期：

页码：

199-203

DOI：

10.1292/jvms.10-0236

基金类别：

Department of Education of Hunan Province, P.R. China [03A020]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

The study was designed to explore the toxic effects of arsanilic acid on piglet Sertoli cells. Sertoli cells were isolated from piglet testes using a two-step enzyme digestion followed by differential plating. Piglet Sertoli cells were cultured and classified into the following five groups: group A, the control without arsanilic acid treatment; group B, cultured with 5 mu M arsanilic acid; group C, cultured with 50 mu M arsanilic acid; group D, cultured with 0.5 mM arsanilic acid; and group E, cultured with 5 mM arsanilic acid. We found that Sertoli cell growth was inhibited by arsanilic acid ...

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DNA Damage and Decrease of Cellular Oxidase Activity in Piglet Sertoli Cells Exposed to Arsanilic Acid

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