Characterization of gelsevirine metabolites in rat liver S9 by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

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成果类型：

期刊论文

作者：

Zhang, Hua-Hai;Huang, Ya-Jun;Liu, Yan-Chun;Jiang, Xu-Yan;Zhang, Shuo-Xin*;...

通讯作者：

Zhang, Shuo-Xin;Liu, Zhao-Ying

作者机构：

[Zhang, Shuo-Xin; Zhang, Hua-Hai] Northwest A&F Univ, Coll Forestry, 3 Taicheng Rd, Yangling 712100, Shaanxi, Peoples R China.

[Liu, Zhao-Ying; Liu, Yan-Chun; Huang, Ya-Jun] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Zhang, Shuo-Xin; Zhang, Hua-Hai] Qinling Natl Forest Ecosyst Res Stn, Ningshan 711600, Shaanxi, Peoples R China.

[Liu, Zhao-Ying] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet, Changsha 410128, Hunan, Peoples R China.

[Jiang, Xu-Yan] Northwest A&F Univ, Coll Landscape Architecture & Arts, 3 Taicheng Rd, Yangling 712100, Shaanxi, Peoples R China.

通讯机构：

[Zhang, Shuo-Xin] N

[Liu, Zhao-Ying] H

Northwest A&F Univ, Coll Forestry, 3 Taicheng Rd, Yangling 712100, Shaanxi, Peoples R China.

Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

语种：

英文

期刊：

Rapid Communications in Mass Spectrometry

ISSN：

0951-4198

年：

2019

卷：

期：

页码：

1179-1184

DOI：

10.1002/rcm.8457

基金类别：

Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2017JJ1017]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [18A088]

机构署名：

本校为通讯机构

院系归属：

动物医学院

摘要：

Rationale: Gelsemium elegans Benth. belongs to the family Loganiaceae and is widely distributed in northern America, east Asia, and southeast Asia. It has attracted wide attention for its diverse biological effects and complex architectures. Gelsevirine is one of the major components in G. elegans. Compared with other alkaloids from G. elegans, gelsevirine exhibits equally potent anxiolytic effects but with less toxicity. However, the metabolism of gelsevirine has not been clearly elucidated. Methods: The metabolism of gelsevirine was investiga...

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Characterization of gelsevirine metabolites in rat liver S9 by accurate mass measurements using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

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