Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

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成果类型：

期刊论文

作者：

Pang, Yilin;Tan, Guoqiang;Yang, Xunjun;Lin, Yuanshan;Chen, Yao;...

通讯作者：

Lyu, Jianxin;Wang, Zheng

作者机构：

[Wang, Zheng; Fang, Jun; Lin, Yuanshan; Pang, Yilin] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Xie, Ting; Ren, Xiaojun; Zhou, Huaibin; Lyu, Jianxin; Tan, Guoqiang; Yang, Xunjun; Zhao, Qiongya; Pang, Yilin; Li, Jianghui; Zhang, Jinping] Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ, Wenzhou 325035, Zhejiang, Peoples R China.

[Yang, Xunjun] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Lab Med, Wenzhou 325027, Zhejiang, Peoples R China.

[Lyu, Jianxin] Hangzhou Med Coll, Peoples Hosp, Hangzhou 310014, Peoples R China.

[Chen, Yao] Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou, Peoples R China.

通讯机构：

[Lyu, Jianxin] Z

[Wang, Zheng] C

Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.

People's Hospital of Hangzhou Medical College, Hangzhou, 310014, China.

College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 410128, Hunan, China.

语种：

英文

关键词：

LYRM4;Hepatocellular carcinoma;Prognosis;Diagnostic biomarker;Functional network analysis

期刊：

Cancer Cell International

ISSN：

1475-2867

年：

2021

卷：

期：

页码：

1-22

DOI：

10.1186/s12935-021-02131-3

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31071531, 81671124, 31870775, 31772642]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2019JJ40134]; Scientific Research Project of Hunan Education Department [18A098]; Hunan Provincial Graduate Research and Innovation Project [CX2018B404]; Key Discipline of Zhejiang Province in Medical Technology (first class, category A), Double first-class construction project of Hunan Agricultural University [SYL201802003]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019T120705]

机构署名：

本校为第一机构

院系归属：

生物科学技术学院

摘要：

BACKGROUND: LYRM4 is necessary to maintain the stability and activity of the human cysteine desulfurase complex NFS1-LYRM4-ACP. The existing experimental results indicate that cancer cells rely on the high expression of NFS1. However, the role of LYRM4 in liver hepatocellular carcinoma (LIHC) remains unclear. METHODS: In this study, we combined bioinformatics analysis and clinical specimens to evaluate the mRNA, protein expression, and gene regulatory network of LYRM4 in LIHC. Furthermore, we detected the activity of several classical iron-sulphur proteins in LIHC cell lines through UV-vis spe...

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Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

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