A potential mechanism for the anti-Apoptotic property of koumine involving mitochondrial pathway in LPS-Mediated RAW264.7 Macrophages

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成果类型：

期刊论文

作者：

Yuan, Zhi-Hang;Liang, Zeng-Enni;Wu, Jing;Yi, Jin-E;Chen, Xiao-Jun;...

通讯作者：

Sun, Zhi-Liang

作者机构：

[Wu, Jing; Yi, Jin-E; Sun, Zhi-Liang; Yuan, Zhi-Hang; Chen, Xiao-Jun] Hunan Agr Univ, Dept Clin Vet Med, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Wu, Jing; Yi, Jin-E; Sun, Zhi-Liang; Yuan, Zhi-Hang; Chen, Xiao-Jun] Hunan Coinnovat Ctr Utilizat Bot Funct Ingredient, Changsha 410128, Hunan, Peoples R China.

[Liang, Zeng-Enni] Dept Hunan Agr Product Proc Inst, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Sun, Zhi-Liang] H

Hunan Agr Univ, Dept Clin Vet Med, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

Hunan Coinnovat Ctr Utilizat Bot Funct Ingredient, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Bcl2 protein, mouse;indole alkaloid;koumine;lipopolysaccharide;monokine;nitric oxide;protein bcl 2;animal;apoptosis;biosynthesis;drug effects;gene expression regulation;metabolism;mitochondrion;mouse;RAW 264.7 cell line;signal transduction;Animals;Apoptosis;Gene Expression Regulation;Indole Alkaloids;Lipopolysaccharides;Mice;Mitochondria;Monokines;Nitric Oxide;Proto-Oncogene Proteins c-bcl-2;RAW 264.7 Cells;Signal Transduction

期刊：

Molecules

ISSN：

1420-3049

年：

2016

卷：

期：

页码：

1317

DOI：

10.3390/molecules21101317

基金类别：

This study is supported by the National Natural Science Foundation of China (Grant No. 31572563; Grant No. 31501484; Grant No. 31302157) and the Hunan Provincial Natural Science Foundation of China (Grant No. 2016JJ3081).

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Koumine is a kind of alkaloid extracted from Gelsemium elegans (G. elegans). Benth, which has shown promise as an anti-Tumor, anxiolytic, and analgesic agent. In our present study, the effect of koumine on lipopolysaccharide (LPS)-mediated RAW 264.7 cell apoptosis was evaluated. MTT assays showed that koumine obviously increased cell viability in LPS-mediated RAW 264.7 macrophages. Preincubation with koumine ameliorated LPS-medicated apoptosis by decreasing reactive oxygen species (ROS) production, which resulted in a significant decrease in th...

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A potential mechanism for the anti-Apoptotic property of koumine involving mitochondrial pathway in LPS-Mediated RAW264.7 Macrophages

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