Systems pharmacology-based optimization of Ma Xing Shi Gan components for the enhanced treatment of chick health issues caused by infectious bronchitis virus

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成果类型：

期刊论文

作者：

Liu, Huixin;He, Yang;Wang, Chenchen;Wei, Xiaofang;Chen, Jiayi*;...

通讯作者：

Chen, Jiayi;Wang, KJ

作者机构：

[Chen, Jiayi; Liu, Huixin; Wang, Kaijun] Changsha Med Univ, Hunan Prov Key Lab Tradit Chinese Med Agr Biogenom, Changsha, Peoples R China.

[Liu, Huixin] Sichuan Acad Chinese Med Sci, Anim Expt Ctr, Chengdu, Peoples R China.

[Liu, Huixin; Wang, Chenchen; Wei, Xiaofang; He, Yang] Guangxi Univ, Coll Anim Sci & Technol, Key Lab Anim Breeding Dis Control & Prevent, Nanning, Peoples R China.

[Wang, Kaijun] Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

[Liu, Huixin] Sichuan Inst Tradit Chinese Med, Expt Anim Ctr, Chengdu, Sichuan, Peoples R China.

通讯机构：

[Chen, JY; Wang, KJ ] C

Changsha Med Univ, Hunan Prov Key Lab Tradit Chinese Med Agr Biogenom, Changsha, Peoples R China.

Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

infectious bronchitis virus;traditional Chinese medicine inheritance computing platform;vitro and in vivo experiments;liquid chromatography-mass spectrometry;network pharmacology

期刊：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ISSN：

2235-2988

年：

2025

卷：

页码：

1585293

DOI：

10.3389/fcimb.2025.1585293

机构署名：

本校为通讯机构

院系归属：

动物医学院

摘要：

INTRODUCTION: Infectious bronchitis virus (IBV) imposes severe economic burdens on the poultry industry, and current treatments face challenges in efficacy and sustainability, necessitating the development of novel therapeutic strategies. To address this, this study employed the Traditional Chinese Medicine Inheritance Computing Platform (TCMICS) to collect clinical prescriptions for IBV treatment, based on which two optimized versions of the traditional Chinese medicine Maxing Shigan Decoction (MXSG), namely MXSG-mix1 and MXSG-mix2, were designed. In vitro cell culture and in vivo chicken mod...

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Systems pharmacology-based optimization of Ma Xing Shi Gan components for the enhanced treatment of chick health issues caused by infectious bronchitis virus

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