Rapid annotation and structural characterization of saponins in the active fraction of Albizia julibrissin by high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry based on accurate mass database

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成果类型：

期刊论文

作者：

He, Yanfei;Ni, Tiantian;Liu, Zhaoying;Ye, Yiping;Sun, Hongxiang*

通讯作者：

Sun, Hongxiang

作者机构：

[He, Yanfei; Ni, Tiantian; Sun, Hongxiang] Zhejiang Univ, Coll Anim Sci, Lab Nat Drug, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China

[Liu, Zhaoying] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Vet Drug, Changsha, Hunan, Peoples R China

[Ye, Yiping] Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou, Zhejiang, Peoples R China

通讯机构：

[Sun, Hongxiang] Z

Zhejiang Univ, Coll Anim Sci, Lab Nat Drug, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China.

语种：

英文

关键词：

Database systems;High performance liquid chromatography;Liquids;Mass spectrometry;Metabolites;Purification;Structure (composition);Accurate-mass database;Active fraction;Albizia julibrissin;Molecular formula;Quadrupole time of flight mass spectrometry;Structural characterization;Tandem mass spectrometry;High pressure liquid chromatography;acacigenin B;adianthifolioside B;albiziasaponin B;albiziasaponin B1;albiziatrioside A;albiziatrioside A1;hehuanoside A;julibrogenin C;julibroside A1;julibroside A4;julibroside C1;julibroside J22;julibroside J26;julibroside J31;julibroside J31a;julibroside J32;proceraoside D;prosapogenin 10;prosapogenin 10a;prosapogenin 10b;prosapogenin 12;prosapogenin 12a;prosapogenin 12b;prosapogenin 9;prosapogenin 9a;prosapogenin 9b;saponin;unclassified drug;unindexed drug;zygiaoside D;zygiaoside D1;saponin;Albizia;Albizia julibrissin;Article;drug structure;high performance liquid chromatography;molecular weight;priority journal;time of flight mass spectrometry;Albizia;chemistry;conformation;isolation and purification;mass spectrometry;time factor;Albizzia;Chromatography, High Pressure Liquid;Mass Spectrometry;Molecular Conformation;Saponins;Time Factors

期刊：

JOURNAL OF SEPARATION SCIENCE

ISSN：

1615-9306

年：

2019

卷：

期：

页码：

2922-2941

DOI：

10.1002/jssc.201900421

基金类别：

The raw data are available online from MetaboLight (https://www.ebi.ac.uk/metabolights/) under the following accession numbers: MTBLS10174. This work was supported by Grant-in-Aid from the National Key R&D Program of China (2017YFD0501505), theNational Natural Science Foundation of China (31272597, 31472229, and 31772783), the Zhejiang Provincial Natural Science Foundation of China (No. LZ13C180001), and the Dabeinong Funds for Discipline Development and Talent Training in Zhejiang University.

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本校为其他机构

院系归属：

动物医学院

摘要：

The purified active fraction of Albizia julibrissin saponin was proved to be a promising adjuvant candidate for vaccine. In this study, a simple, convenient, and practical strategy was established for characterizing the saponins in this purified active fraction. The personal accurate mass database including chemical structure, molecular formula, and theoretical mass was first constructed by collecting 110 reported known saponins from genus Albizia species. The raw data was obtained by high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry. The potential...

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Rapid annotation and structural characterization of saponins in the active fraction of Albizia julibrissin by high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry based on accurate mass database

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