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Optimized animal model to mimic the reality of stress-induced depression in the clinic

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成果类型:
期刊论文
作者:
Zhang, Yi;Wang, Yuting;Lei, Hui;Wang, Lei;Xue, Liang;...
通讯作者:
Zhu, Xiongzhao
作者机构:
[Wang, Xin; Zhu, Xiongzhao; Xue, Liang; Wang, Lei; Zhang, Yi] Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China.
[Wang, Yuting] Maternal & Child Hlth Hosp Hunan Prov, Dept Clin Psychol, Changsha 410008, Hunan, Peoples R China.
[Lei, Hui] Hunan Agr Univ, Coll Educ, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Zhu, Xiongzhao] C
Cent S Univ, Xiangya Hosp 2, Med Psychol Ctr, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China.
语种:
英文
关键词:
Depression;Animal model;Latent profile analysis;Percentile method;Cutoff
期刊:
BMC Psychiatry
ISSN:
1471-244X
年:
2017
卷:
17
期:
1
页码:
1-9
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671341]
机构署名:
本校为其他机构
院系归属:
教育学院
摘要:
Animal models are useful tools for verifying the relationship between stress and depression; however, an operational criterion for excluding the resilient animals from the analysis has not been established yet, which hinders the model’s ability to more accurately mimic the scenario in humans. To induce depression-like symptoms, rats received maternal deprivation (MD) during PND1–14, and/or chronic unpredictable stress (CUS) exposure. The latent profile analysis (LPA) was used to determine latent subgroups in treatment naive adult rats. The pe...

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