期刊论文

Xiang Zhao

英文

International Journal of Biological Macromolecules

0141-8130

2023

240

124384

10.1016/j.ijbiomac.2023.124384

CRediT authorship contribution statement X. Zhao conceived the ideas and designed the experiments. X. Zhao, S.T. Xiong and Y. R. Ying and Z. Long performed the majority of experiments. X. Zhao, S. T. Xiong and T. Y. Xiao is responsible for funding acquisition. S.T. Xiong write the original draft. X. Zhao and J. H. Li critically revised the manuscript. X. Zhao supervised the study. All authors discussed the results and commented on the manuscript.

本校为第一机构

Membrane-associated RING-CH-type finger (MARCH) proteins have been reported to regulate type I IFN production during host antiviral innate immunity. The present study reported the zebrafish MARCH family member, MARCH7, as a negative regulator in virus-triggered type I IFN induction via targeting TANK-binding kinase 1 (TBK1) for degradation. As an IFN-stimulated gene (ISG), we discovered that MARCH7 was significantly induced by spring viremia of carp virus (SVCV) or poly(I:C) stimulation. Ectopic expression of MARCH7 reduced the activity of IFN promoter and dampened the cellular antiviral respo...