Procyanidins B2 reverses the T-2 toxin-induced mitochondrial apoptosis in TM3 Leydig cells

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成果类型：

期刊论文

作者：

Wn, Jing;Huang, Weimei;Xiao, Haisi;Xie, Yi;Yuan, Zhihang;...

通讯作者：

Tu, Di;Tian, Yanan

作者机构：

[Tu, Di; Tian, Yanan; Yi, Jine; Wn, Jing; Huang, Weimei; Xiao, Haisi; Yuan, Zhihang] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Chen, Jingshu; Tian, Yanan] Texas A&M Univ, Coll Vet Med, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA.

[Xie, Yi] Yiyang Vocat & Tech Coll, Yiyang 413000, Hunan, Peoples R China.

[Wn, Jing; Yuan, Zhihang] Hunan Agr Univ, Hunan Collaborat Innovat Utilizat Bot Funct Ingre, Changsha 410128, Hunan, Peoples R China.

[Wn, Jing; Yuan, Zhihang] Hunan Agr Univ, Hunan Engn Res Ctr Vet Drug, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Tu, D; Tian, YN] H

Hunan Agr Univ HAU, Coll Vet Med, 1 Nongdalu Rd, Changsha 100071, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Oxidative stress;Procyanidins B2;T-2 toxin

期刊：

Journal of Functional Foods

ISSN：

1756-4646

年：

2018

卷：

页码：

118-128

DOI：

10.1016/j.jff.2018.03.038

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31302157]; NIEHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [P30 E5023512]

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Procyanidins B2 (PB2) was found to block T-2 toxin-induced reproductive toxicity and may be used as a dietary preventive agent. We investigated the mechanism of PB2 in blocking the T-2 toxin-induced apoptosis in Leydig cells in conjunction with analysis of T-2 toxin induced proapoptotic responses in Leydig cells including induction of oxidative stresses. The stress inducible proteins ASK, p38 and JNK were increased in response to T-2 toxin and the induction was attenuated by PB2. Furthermore, we showed that T-2 toxin suppressed mitochondrial me...

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Procyanidins B2 reverses the T-2 toxin-induced mitochondrial apoptosis in TM3 Leydig cells

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